3M76
 
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3M73
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7D57
 | | C-Src in complex with FIIN-2 | | 分子名称: | N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION | | 著者 | Chen, Y.H, Qu, L.Z. | | 登録日 | 2020-09-25 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.104 Å) | | 主引用文献 | Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
Commun Chem, 5, 2022
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8GVJ
 | | Crystal structure of cMET kinase domain bound by D6808 | | 分子名称: | (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor | | 著者 | Chen, Y.H, Qu, L.Z. | | 登録日 | 2022-09-15 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.
J.Med.Chem., 65, 2022
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7XPQ
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7XPO
 | | Crystal Structure of UDP-Glc/GlcNAc 4-Epimerase with NAD/UDP-Glc | | 分子名称: | GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-glucose 4-epimerase, ... | | 著者 | Chen, Y.H, Wang, X.C, Zhang, C.R. | | 登録日 | 2022-05-05 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis.
Nat Commun, 14, 2023
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7XPP
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8XLO
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8XLQ
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4YM4
 | | Truncated Human TIFA in complex with its Thr9 phosphorylated N-terminal peptide 1-15 | | 分子名称: | TRAF-interacting protein with FHA domain-containing protein A | | 著者 | Weng, J.H, Wei, T.Y.W, Hsieh, Y.C, Huang, C.C.F, Wu, P.Y.G, Chen, E.S.W, Huang, K.F, Chen, C.J, Tsai, M.D. | | 登録日 | 2015-03-06 | | 公開日 | 2015-10-21 | | 最終更新日 | 2015-10-28 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.
Biochemistry, 54, 2015
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1XWO
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4HI3
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4X8C
 | | Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with GSK147 | | 分子名称: | CALCIUM ION, Protein-arginine deiminase type-4, [(3S,4R)-3-amino-4-hydroxypiperidin-1-yl]{2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl}methanone | | 著者 | Lewis, H.D, Bax, B.D, Chung, C.-W, Polyakova, O, Thorpe, J. | | 登録日 | 2014-12-10 | | 公開日 | 2015-01-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat.Chem.Biol., 11, 2015
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4X8G
 | | Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with GSK199 | | 分子名称: | CALCIUM ION, Protein-arginine deiminase type-4, [(3R)-3-aminopiperidin-1-yl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]methanone | | 著者 | Lewis, H.D, Bax, B.D, Chung, C.-W, Polyakova, O, Thorpe, J. | | 登録日 | 2014-12-10 | | 公開日 | 2015-01-28 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat.Chem.Biol., 11, 2015
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4ZGI
 | | Structure of Truncated Human TIFA | | 分子名称: | TRAF-interacting protein with FHA domain-containing protein A | | 著者 | Weng, J.H, Wei, T.Y.W, Hsieh, Y.C, Huang, C.C.F, Wu, P.Y.G, Chen, E.S.W, Huang, K.F, Chen, C.J, Tsai, M.D. | | 登録日 | 2015-04-23 | | 公開日 | 2015-10-14 | | 最終更新日 | 2015-10-28 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.
Biochemistry, 54, 2015
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7CBY
 | | Structure of FOXG1 DNA binding domain bound to DBE2 DNA site | | 分子名称: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), ... | | 著者 | Dai, S.Y, Li, J, Chen, Y.H. | | 登録日 | 2020-06-15 | | 公開日 | 2020-10-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.646 Å) | | 主引用文献 | Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations.
J.Mol.Biol., 432, 2020
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3ERF
 | | Crystal structure of Gtt2 from Saccharomyces cerevisiae | | 分子名称: | Glutathione S-transferase 2 | | 著者 | Ma, X.X, Jiang, Y.L, He, Y.X, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2008-10-02 | | 公開日 | 2009-10-13 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family.
Embo Rep., 10, 2009
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6TB3
 | | yeast 80S ribosome in complex with the Not5 subunit of the CCR4-NOT complex | | 分子名称: | 25S rRNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | 著者 | Buschauer, R, Cheng, J, Berninghausen, O, Tesina, P, Becker, T, Beckmann, R. | | 登録日 | 2019-10-31 | | 公開日 | 2020-04-22 | | 最終更新日 | 2020-04-29 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Science, 368, 2020
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6TNU
 | | Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs. | | 分子名称: | 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | 著者 | Buschauer, R, Cheng, J, Berninghausen, O, Tesina, P, Becker, T, Beckmann, R. | | 登録日 | 2019-12-10 | | 公開日 | 2020-04-22 | | 最終更新日 | 2020-04-29 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Science, 368, 2020
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5AWV
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5EGM
 | | Development of a novel tricyclic class of potent and selective FIXa inhibitors | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-chloranyl-~{N}-[(7~{S})-2-methyl-7-phenyl-10-(1~{H}-1,2,3,4-tetrazol-5-yl)-8,9-dihydro-6~{H}-pyrido[1,2-a]indol-7-yl]-4-(1,2,4-triazol-4-yl)benzamide, Coagulation factor IX, ... | | 著者 | Meng, D, Andre, P, Bateman, T.J, Berger, R, Chen, Y, Desai, K, Dewnani, S, Ellsworth, K, Feng, D, Geissler, W.M, Guo, L, Hruza, A, Jian, T, Li, H, Parker, D.L, Reichert, P, Sherer, E.C, Smith, C.J, Sonatore, L.M, Tschirret-Guth, R, Wu, J, Xu, J, Zhang, T, Campeau, L, Orr, R, Poirier, M, McCabe-Dunn, j, Araki, K, Nishimura, T, Sakurada, I, Hirabayashi, T, Wood, H.B. | | 登録日 | 2015-10-27 | | 公開日 | 2015-11-18 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.841 Å) | | 主引用文献 | Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
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7WUH
 | | SARS-CoV-2 Spike in complex with Fab of m31A7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chen, X, Wu, Y.-M. | | 登録日 | 2022-02-08 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.
Sci Transl Med, 14, 2022
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7WUE
 | | Crystal structure of SARS-CoV-2 Receptor Binding Domain in complex with the monoclonal antibody m31A7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Mohapatra, A. | | 登録日 | 2022-02-08 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.
Sci Transl Med, 14, 2022
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5GPK
 | | Crystal structure of Ccp1 mutant | | 分子名称: | Putative nucleosome assembly protein C36B7.08c | | 著者 | Yin, F, Gao, F, Chen, Y. | | 登録日 | 2016-08-03 | | 公開日 | 2016-11-30 | | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | | 主引用文献 | Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading
Mol.Cell, 64, 2016
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5GPL
 | | Crystal structure of Ccp1 | | 分子名称: | Putative nucleosome assembly protein C36B7.08c | | 著者 | Yin, F, Gao, F, Chen, Y. | | 登録日 | 2016-08-03 | | 公開日 | 2016-11-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading
Mol.Cell, 64, 2016
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