Truncated Human TIFA in complex with its Thr9 phosphorylated N-terminal peptide 1-15

Summary for 4YM4

DescriptorTRAF-interacting protein with FHA domain-containing protein A (2 entities in total)
Functional Keywordscomplex, fha domian, adaptor, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight18303.88
Weng, J.H.,Wei, T.Y.W.,Hsieh, Y.C.,Huang, C.C.F.,Wu, P.Y.G.,Chen, E.S.W.,Huang, K.F.,Chen, C.J.,Tsai, M.D. (deposition date: 2015-03-06, release date: 2015-10-21, Last modification date: 2015-10-28)
Primary citation
Weng, J.H.,Hsieh, Y.C.,Huang, C.C.,Wei, T.Y.,Lim, L.H.,Chen, Y.H.,Ho, M.R.,Wang, I.,Huang, K.F.,Chen, C.J.,Tsai, M.D.
Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.
Biochemistry, 54:6219-6229, 2015
PubMed: 26389808 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.5b00500
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21419019.4%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4ym4
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Molmil generated image of 4ym4
rotated about x axis by 90°
Molmil generated image of 4ym4
rotated about y axis by 90°