4X8G

Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with GSK199

Summary for 4X8G

• Entry DOI: 10.2210/pdb4x8g/pdb
• Related: 4X8C
• Descriptor: Protein-arginine deiminase type-4, CALCIUM ION, [(3R)-3-aminopiperidin-1-yl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]methanone, ... (4 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q9UM07
• Total number of polymer chains: 1
• Total formula weight: 75510.67

Authors

Lewis, H.D.,Bax, B.D.,Chung, C.-W.,Polyakova, O.,Thorpe, J. (deposition date: 2014-12-10, release date: 2015-01-28, Last modification date: 2024-02-28)

• Primary citation: Lewis, H.D.,Liddle, J.,Coote, J.E.,Atkinson, S.J.,Barker, M.D.,Bax, B.D.,Bicker, K.L.,Bingham, R.P.,Campbell, M.,Chen, Y.H.,Chung, C.W.,Craggs, P.D.,Davis, R.P.,Eberhard, D.,Joberty, G.,Lind, K.E.,Locke, K.,Maller, C.,Martinod, K.,Patten, C.,Polyakova, O.,Rise, C.E.,Rudiger, M.,Sheppard, R.J.,Slade, D.J.,Thomas, P.,Thorpe, J.,Yao, G.,Drewes, G.,Wagner, D.D.,Thompson, P.R.,Prinjha, R.K.,Wilson, D.M.; Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.; Nat.Chem.Biol., 11:189-191, 2015; PubMed: 25622091; DOI: 10.1038/nchembio.1735

Experimental method

X-RAY DIFFRACTION (3.29 Å)