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Crystal Structure of Agobacterium tumefaciens repressor BlcR
Descriptor:	Transcriptional repressor of the blcABC operon
Authors:	Chen, L.
Deposit date:	2010-04-27
Release date:	2011-03-30
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.793 Å)
Cite:	The Agrobacterium tumefaciens Transcription Factor BlcR Is Regulated via Oligomerization. J.Biol.Chem., 286, 2011

5ZBG

Cryo-EM structure of human TRPC3 at 4.36A resolution
Descriptor:	Short transient receptor potential channel 3
Authors:	Chen, L, Tang, Q, Guo, W.
Deposit date:	2018-02-11
Release date:	2018-05-09
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.36 Å)
Cite:	Structure of the receptor-activated human TRPC6 and TRPC3 ion channels Cell Res., 28, 2018

5YX9

Cryo-EM structure of human TRPC6 at 3.8A resolution
Descriptor:	Short transient receptor potential channel 6
Authors:	Chen, L, Tang, Q, Guo, W.
Deposit date:	2017-12-02
Release date:	2018-05-23
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Structure of the receptor-activated human TRPC6 and TRPC3 ion channels. Cell Res., 28, 2018

3RJ2

Structural and functional characterization of a novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus (SGIV)
Descriptor:	Putative uncharacterized protein
Authors:	Chen, L, Liu, Y, Sivaraman, J, Hew, C.L.
Deposit date:	2011-04-15
Release date:	2012-02-29
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus J.Virol., 85, 2011

6IMM

Cryo-EM structure of an alphavirus, Sindbis virus
Descriptor:	Assembly protein E3, Octadecane, Spike glycoprotein E1, ...
Authors:	Zhang, X, Ma, J, Chen, L.
Deposit date:	2018-10-23
Release date:	2019-03-13
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Implication for alphavirus host-cell entry and assembly indicated by a 3.5 angstrom resolution cryo-EM structure. Nat Commun, 9, 2018

7D4P

Structure of human TRPC5 in complex with clemizole
Descriptor:	(2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, ...
Authors:	Chen, L, Song, K, Wei, M, Guo, W.
Deposit date:	2020-09-24
Release date:	2021-03-31
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021

7D4Q

Structure of human TRPC5 in complex with HC-070
Descriptor:	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione, CALCIUM ION, ...
Authors:	Chen, L, Song, K, Wei, M, Guo, W.
Deposit date:	2020-09-24
Release date:	2021-03-31
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (2.74 Å)
Cite:	Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021

7E4T

Human TRPC5 apo state structure at 3 angstrom
Descriptor:	(2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ...
Authors:	Chen, L, Song, K, Wei, M, Guo, W.
Deposit date:	2021-02-15
Release date:	2021-03-31
Last modified:	2021-10-13
Method:	ELECTRON MICROSCOPY (3 Å)
Cite:	Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021

7E28

Crystal structure of SDR family NAD(P)-dependent oxidoreductase from Exiguobacterium
Descriptor:	Oxidoreductase
Authors:	Chen, L, Tang, J, Yuan, S.
Deposit date:	2021-02-05
Release date:	2021-09-29
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (1.83 Å)
Cite:	Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters Catalysis Science And Technology, 2021

7E24

Crystal structure of SDR family NAD(P)-dependent oxidoreductase from Exiguobacterium
Descriptor:	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase
Authors:	Chen, L, Tang, J, Yuan, S.
Deposit date:	2021-02-04
Release date:	2021-09-29
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.7203 Å)
Cite:	Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters Catalysis Science And Technology, 2021

8K5G

Structure of the SARS-CoV-2 BA.1 RBD with UT28-RD
Descriptor:	Spike protein S1, UT28K-RD Fab Heavy chain, UT28K-RD Fab Light chain
Authors:	Chen, L, Kita, S, Anraku, Y, Maenaka, K.
Deposit date:	2023-07-21
Release date:	2023-12-27
Method:	ELECTRON MICROSCOPY (3.41 Å)
Cite:	In silico-designed UT28K with two amino acid substitutions is capable of neutralization of resistant SARS-CoV2 Omicrons BA.1 valiant. To Be Published

8K5H

Structure of the SARS-CoV-2 BA.1 spike with UT28-RD
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Chen, L, Kita, S, Anraku, Y, Maenaka, K.
Deposit date:	2023-07-21
Release date:	2023-12-27
Method:	ELECTRON MICROSCOPY (3.22 Å)
Cite:	In silico-designed UT28K with two amino acid substitutions is capable of neutralization of resistant SARS-CoV2 Omicrons BA.1 valiant. To Be Published

6L48

Structure of the human sterol O-acyltransferase 1 in resting state
Descriptor:	CHOLESTEROL, Sterol O-acyltransferase 1
Authors:	Chen, L, Guan, C, Niu, Y.
Deposit date:	2019-10-16
Release date:	2020-04-29
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun, 11, 2020

6L47

Structure of the human sterol O-acyltransferase 1 in complex with CI-976
Descriptor:	2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CHOLESTEROL, Sterol O-acyltransferase 1
Authors:	Chen, L, Guan, C, Niu, Y.
Deposit date:	2019-10-16
Release date:	2020-04-29
Last modified:	2020-10-07
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun, 11, 2020

7Y4S

Structure of human MG53 homo-dimer
Descriptor:	Tripartite motif-containing protein 72
Authors:	Chen, L, Niu, Y.
Deposit date:	2022-06-16
Release date:	2022-09-21
Last modified:	2023-04-05
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Cryo-EM structure of human MG53 homodimer. Biochem.J., 479, 2022

7L7S

Human mitochondrial chaperonin mHsp60
Descriptor:	60 kDa heat shock protein, mitochondrial
Authors:	Chen, L, Wang, J.C.Y.
Deposit date:	2020-12-30
Release date:	2021-08-25
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60. Sci Rep, 11, 2021

5YKF

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2019-11-06
Method:	ELECTRON MICROSCOPY (4.33 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YKG

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.57 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YKE

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.11 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWC

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.3 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YW9

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (5 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWB

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-30
Last modified:	2019-11-06
Method:	ELECTRON MICROSCOPY (5.2 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YW8

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5Z1F

Structure of atOSCA3.1 channel
Descriptor:	CSC1-like protein ERD4
Authors:	Chen, L, Zhang, M, Kang, Y, Wu, J.X.
Deposit date:	2017-12-26
Release date:	2018-09-12
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.8 Å)
Cite:	Structure of the mechanosensitive OSCA channels. Nat. Struct. Mol. Biol., 25, 2018

5YWD

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, MAGNESIUM ION
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

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