8K5H

Structure of the SARS-CoV-2 BA.1 spike with UT28-RD

Summary for 8K5H

• Entry DOI: 10.2210/pdb8k5h/pdb
• EMDB information: 36906
• Descriptor: Spike glycoprotein, UT28K-RD Fab heavy chain, UT28K-RD Fab light chain, ... (5 entities in total)
• Functional Keywords: sars-cov-2, antibody, spike protein, structural protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV,SARS-CoV-2); More
• Total number of polymer chains: 5
• Total formula weight: 463435.17

Authors

Chen, L.,Kita, S.,Anraku, Y.,Maenaka, K. (deposition date: 2023-07-21, release date: 2023-12-27, Last modification date: 2024-07-10)

• Primary citation: Ozawa, T.,Ikeda, Y.,Chen, L.,Suzuki, R.,Hoshino, A.,Noguchi, A.,Kita, S.,Anraku, Y.,Igarashi, E.,Saga, Y.,Inasaki, N.,Taminishi, S.,Sasaki, J.,Kirita, Y.,Fukuhara, H.,Maenaka, K.,Hashiguchi, T.,Fukuhara, T.,Hirabayashi, K.,Tani, H.,Kishi, H.,Niimi, H.; Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.; Structure, 32:263-272.e7, 2024; PubMed: 38228146; DOI: 10.1016/j.str.2023.12.013

Experimental method

ELECTRON MICROSCOPY (3.22 Å)