5WR5
| Thermolysin, liganded form with cryo condition 1 | Descriptor: | CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, TETRAETHYLENE GLYCOL, ... | Authors: | Kunishima, N, Naitow, H, Matsuura, Y. | Deposit date: | 2016-11-29 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
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5WR3
| Thermolysin, SFX liganded form with water-based carrier | Descriptor: | CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, Thermolysin, ... | Authors: | Kunishima, N, Naitow, H, Matsuura, Y. | Deposit date: | 2016-11-29 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
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5WR6
| Thermolysin, liganded form with cryo condition 2 | Descriptor: | CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, Thermolysin, ... | Authors: | Kunishima, N, Naitow, H, Matsuura, Y. | Deposit date: | 2016-11-29 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
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4PK6
| Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with imidazothiazole derivative | Descriptor: | Indoleamine 2,3-dioxygenase 1, N-[2-(3-chlorophenyl)ethyl]-3-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-5-carboxamide, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Kohno, T, Tojo, S, Ishii, T, Kamioka, S. | Deposit date: | 2014-05-13 | Release date: | 2014-09-03 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. Acs Med.Chem.Lett., 5, 2014
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8H1J
| Cryo-EM structure of the TnpB-omegaRNA-target DNA ternary complex | Descriptor: | Non-target strand, RNA-guided DNA endonuclease TnpB, Target strand, ... | Authors: | Nakagawa, R, Hirano, H, Omura, S, Nureki, O. | Deposit date: | 2022-10-03 | Release date: | 2023-04-12 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structure of the transposon-associated TnpB enzyme. Nature, 616, 2023
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4PK5
| Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with Amg-1 | Descriptor: | Indoleamine 2,3-dioxygenase 1, N-(1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetamide, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Kohno, T, Tojo, S, Ishii, T. | Deposit date: | 2014-05-13 | Release date: | 2014-09-03 | Last modified: | 2020-01-29 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. Acs Med.Chem.Lett., 5, 2014
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6ANL
| Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | Descriptor: | Mitogen-activated protein kinase 14, TAK-715 | Authors: | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | Deposit date: | 2017-08-14 | Release date: | 2018-01-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
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6PU2
| Dark, Mutant H275T , 100K, PCM Myxobacterial Phytochrome, P2 | Descriptor: | 3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid, Photoreceptor-histidine kinase BphP | Authors: | Pandey, S, Schmidt, M, Stojkovic, E.A. | Deposit date: | 2019-07-16 | Release date: | 2019-10-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures. Struct Dyn., 6, 2019
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6PTQ
| Dark, Room Temperature, PCM Myxobacterial Phytochrome, P2, Wild Type | Descriptor: | 3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid, BENZAMIDINE, Photoreceptor-histidine kinase BphP | Authors: | Pandey, S, Schmidt, M, Stojkovic, E.A. | Deposit date: | 2019-07-16 | Release date: | 2019-10-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures. Struct Dyn., 6, 2019
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6PTX
| Dark, 100K, PCM Myxobacterial Phytochrome, P2, Wild Type, | Descriptor: | 3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid, Photoreceptor-histidine kinase BphP | Authors: | Pandey, S, Schmidt, M, Stojkovic, E.A. | Deposit date: | 2019-07-16 | Release date: | 2019-10-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures. Struct Dyn., 6, 2019
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4YOP
| CRYSTAL STRUCTURE OF HEN EGG-WHITE LYSOZYME | Descriptor: | CHLORIDE ION, Lysozyme C, SODIUM ION | Authors: | Sugahara, M, Nakane, T, Suzuki, M, Nango, E. | Deposit date: | 2015-03-12 | Release date: | 2015-12-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Native sulfur/chlorine SAD phasing for serial femtosecond crystallography Acta Crystallogr.,Sect.D, 71, 2015
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6M9L
| Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10 | Descriptor: | 3-benzyl-6-[(2,4-difluorophenyl)amino]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one, Mitogen-activated protein kinase 14 | Authors: | Lane, W, Okada, K. | Deposit date: | 2018-08-23 | Release date: | 2019-04-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1. Chemmedchem, 14, 2019
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6M95
| Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping: compound 1 | Descriptor: | (4-benzylpiperidin-1-yl)[2-methoxy-4-(methylsulfanyl)phenyl]methanone, Mitogen-activated protein kinase 14 | Authors: | Lane, W, Okada, K. | Deposit date: | 2018-08-22 | Release date: | 2019-04-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1. Chemmedchem, 14, 2019
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6OHD
| P38 in complex with T-3220137 | Descriptor: | 3-(3-tert-butyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-4-methyl-N-(1,2-oxazol-3-yl)benzamide, Mitogen-activated protein kinase 14 | Authors: | Lane, W, Saikatendu, K. | Deposit date: | 2019-04-05 | Release date: | 2019-11-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]Pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 2. Chemmedchem, 14, 2019
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1GSH
| STRUCTURE OF ESCHERICHIA COLI GLUTATHIONE SYNTHETASE AT PH 7.5 | Descriptor: | GLUTATHIONE BIOSYNTHETIC LIGASE | Authors: | Matsuda, K, Kato, H, Yamaguchi, H, Nishioka, T, Katsube, Y, Oda, J. | Deposit date: | 1995-05-16 | Release date: | 1996-07-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of glutathione synthetase at optimal pH: domain architecture and structural similarity with other proteins. Protein Eng., 9, 1996
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6CKX
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7YU4
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7YU3
| Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Akasaka, H, Shihoya, W, Nureki, O. | Deposit date: | 2022-08-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
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7YU5
| Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state1 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Akasaka, H, Shihoya, W, Nureki, O. | Deposit date: | 2022-08-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
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7YU7
| Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state3 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Akasaka, H, Shihoya, W, Nureki, O. | Deposit date: | 2022-08-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
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7YU6
| Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state2 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Akasaka, H, Shihoya, W, Nureki, O. | Deposit date: | 2022-08-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
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7YU8
| Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state4 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Akasaka, H, Shihoya, W, Nureki, O. | Deposit date: | 2022-08-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
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1GSA
| STRUCTURE OF GLUTATHIONE SYNTHETASE COMPLEXED WITH ADP AND GLUTATHIONE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLUTATHIONE, GLUTATHIONE SYNTHETASE, ... | Authors: | Hara, T, Kato, H, Nishioka, T, Katsube, Y, Oda, J. | Deposit date: | 1995-06-08 | Release date: | 1996-06-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A pseudo-michaelis quaternary complex in the reverse reaction of a ligase: structure of Escherichia coli B glutathione synthetase complexed with ADP, glutathione, and sulfate at 2.0 A resolution. Biochemistry, 35, 1996
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8K65
| Serial femtosecond crystallography structure of CO bound ba3- type cytochrome c oxidase without pump laser irradiation | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CARBON MONOXIDE, COPPER (II) ION, ... | Authors: | Safari, C, Ghosh, S, Andersson, R, Johannesson, J, Donoso, A.V, Bath, P, Zoric, D, Sandelin, E, Nango, E, Tanaka, R, Iwata, S, Neutze, R, Branden, G. | Deposit date: | 2023-07-25 | Release date: | 2023-11-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase. Sci Adv, 9, 2023
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7ZY3
| Room temperature structure of Archaerhodopsin-3 obtained 110 ns after photoexcitation | Descriptor: | Archaerhodopsin-3, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kwan, T.O.C, Judge, P.J, Moraes, I, Watts, A, Axford, D, Bada Juarez, J.F. | Deposit date: | 2022-05-23 | Release date: | 2023-06-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A versatile approach to high-density microcrystals in lipidic cubic phase for room-temperature serial crystallography. J.Appl.Crystallogr., 56, 2023
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