6OHD

P38 in complex with T-3220137

Summary for 6OHD

Entry DOI	10.2210/pdb6ohd/pdb
Descriptor	Mitogen-activated protein kinase 14, 3-(3-tert-butyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-4-methyl-N-(1,2-oxazol-3-yl)benzamide (3 entities in total)
Functional Keywords	sbdd, p38, kinase, protein binding, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	45080.10
Authors	Lane, W.,Saikatendu, K. (deposition date: 2019-04-05, release date: 2019-11-20, Last modification date: 2024-03-13)
Primary citation	Kaieda, A.,Takahashi, M.,Fukuda, H.,Okamoto, R.,Morimoto, S.,Gotoh, M.,Miyazaki, T.,Hori, Y.,Unno, S.,Kawamoto, T.,Tanaka, T.,Itono, S.,Takagi, T.,Sugimoto, H.,Okada, K.,Lane, W.,Sang, B.C.,Saikatendu, K.,Matsunaga, S.,Miwatashi, S. Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]Pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 2. Chemmedchem, 14:2093-2101, 2019 Cited by PubMed: 31697454 DOI: 10.1002/cmdc.201900373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation