4PK6
Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with imidazothiazole derivative
Summary for 4PK6
Entry DOI | 10.2210/pdb4pk6/pdb |
Related | 4PK5 |
Descriptor | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-[2-(3-chlorophenyl)ethyl]-3-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-5-carboxamide (3 entities in total) |
Functional Keywords | indoleamine 2, 3-dioxygenagse 1, induced fit, structure based drug discovery, imidazothiazole, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : P14902 |
Total number of polymer chains | 2 |
Total formula weight | 97135.92 |
Authors | Kohno, T.,Tojo, S.,Ishii, T.,Kamioka, S. (deposition date: 2014-05-13, release date: 2014-09-03, Last modification date: 2017-10-04) |
Primary citation | Tojo, S.,Kohno, T.,Tanaka, T.,Kamioka, S.,Ota, Y.,Ishii, T.,Kamimoto, K.,Asano, S.,Isobe, Y. Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. Acs Med.Chem.Lett., 5:1119-1123, 2014 Cited by PubMed: 25313323DOI: 10.1021/ml500247w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.45 Å) |
Structure validation
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