2MDJ
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7E0Z
| Crystal structure of PKAc-PLN complex | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PLN, ... | Authors: | Qin, J, Yuchi, Z. | Deposit date: | 2021-01-28 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.162 Å) | Cite: | Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife, 11, 2022
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7E12
| Crystal structure of PKAc-A11E complex | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, THR-ARG-SER-GLU-ILE-ARG-ARG-ALA-SER-THR-ILE-GLU, ... | Authors: | Qin, J, Lin, L, Yuchi, Z. | Deposit date: | 2021-01-28 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.796 Å) | Cite: | Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife, 11, 2022
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7E11
| Crystal structure of PKAc-PLN R9C complex | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PLN, ... | Authors: | Qin, J, Lin, L, Yuchi, Z. | Deposit date: | 2021-01-28 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.43 Å) | Cite: | Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife, 11, 2022
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2MDC
| Solution structure of the WW domain of HYPB | Descriptor: | Histone-lysine N-methyltransferase SETD2 | Authors: | Gao, Y.G. | Deposit date: | 2013-09-10 | Release date: | 2014-09-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin Structure, 22, 2014
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2K3N
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2K3O
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4RSC
| Crystal structure of RPE65 in complex with emixustat and palmitate | Descriptor: | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... | Authors: | Kiser, P.D, Shi, W, Palczewski, K. | Deposit date: | 2014-11-07 | Release date: | 2015-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11, 2015
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8F4O
| Apo structure of the TPP riboswitch aptamer domain | Descriptor: | IRIDIUM HEXAMMINE ION, TETRAETHYLENE GLYCOL, TPP riboswitch aptamer domain, ... | Authors: | Lee, H.-K, Wang, Y.-X, Stagno, J.R. | Deposit date: | 2022-11-11 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of Escherichia coli thiamine pyrophosphate-sensing riboswitch in the apo state. Structure, 31, 2023
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7Y3G
| Cryo-EM structure of a class A orphan GPCR | Descriptor: | G-protein coupled receptor 12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Li, H, Zhang, J.Y, Luo, F. | Deposit date: | 2022-06-10 | Release date: | 2023-06-07 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural insight into the constitutive activity of human orphan receptor GPR12. Sci Bull (Beijing), 68, 2023
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2JBU
| Crystal structure of human insulin degrading enzyme complexed with co- purified peptides. | Descriptor: | 1,4-DIETHYLENE DIOXIDE, CO-PURIFIED PEPTIDE, INSULIN-DEGRADING ENZYME | Authors: | Im, H, Shen, Y, Tang, W.J. | Deposit date: | 2006-12-11 | Release date: | 2007-07-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282, 2007
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2K3Q
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5YZ3
| Crystal structure of T2R-TTL-28 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | Authors: | Yu, Y, Chen, Q. | Deposit date: | 2017-12-12 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.545 Å) | Cite: | A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors. Cancer Res., 78, 2018
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5ZHE
| STRUCTURE OF E. COLI UNDECAPRENYL DIPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-981 | Descriptor: | 2-hydroxy-6-(tetradecyloxy)benzoic acid, Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | Authors: | Gao, J, Liu, W.D, Zheng, Y.Y, Ko, T.P, Chen, C.C, Guo, R.T. | Deposit date: | 2018-03-13 | Release date: | 2019-03-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis. J.Med.Chem., 62, 2019
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2L3T
| Solution structure of tandem SH2 domain from Spt6 | Descriptor: | Transcription elongation factor SPT6 | Authors: | Liu, J, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2010-09-22 | Release date: | 2011-06-15 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain To be Published
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7CM3
| Cryo-EM structure of human NALCN in complex with FAM155A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wu, J, Yan, Z, Ke, M. | Deposit date: | 2020-07-24 | Release date: | 2020-11-11 | Last modified: | 2020-12-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the human sodium leak channel NALCN in complex with FAM155A. Nat Commun, 11, 2020
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6LS4
| A novel anti-tumor agent S-40 in complex with tubulin | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(4-cyclopropylphenyl)sulfonylamino]-4-methyl-N-(pyridin-3-ylmethyl)benzamide, GLYCEROL, ... | Authors: | Du, T, Lin, S, Ji, M, Xue, N, Liu, Y, Zhang, K, Lu, D, Chen, X, Xu, H. | Deposit date: | 2020-01-17 | Release date: | 2021-01-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity. Cancer Lett., 495, 2020
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6V6U
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3UA0
| N-Terminal Domain of Bombyx mori Fibroin Mediates the Assembly of Silk in Response to pH Decrease | Descriptor: | Fibroin heavy chain | Authors: | He, Y.-X, Zhang, N.-N, Chen, B.-Y, Li, W.-F, Chen, Y.-X, Zhou, C.-Z. | Deposit date: | 2011-10-20 | Release date: | 2012-03-28 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | N-Terminal Domain of Bombyx mori Fibroin Mediates the Assembly of Silk in Response to pH Decrease. J.Mol.Biol., 418, 2012
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2MQG
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4P7I
| Crystal structure of the Merlin FERM/DCAF1 complex | Descriptor: | GLYCEROL, Merlin, Protein VPRBP | Authors: | Wei, Z, Li, Y, Zhang, M. | Deposit date: | 2014-03-27 | Release date: | 2014-04-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1. J.Biol.Chem., 289, 2014
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7DTK
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7DTJ
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2K3P
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6LCY
| Crystal structure of Synaptotagmin-7 C2B in complex with IP6 | Descriptor: | INOSITOL HEXAKISPHOSPHATE, Synaptotagmin-7 | Authors: | Zhang, Y, Zhang, X, Rao, F, Wang, C. | Deposit date: | 2019-11-20 | Release date: | 2021-03-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | 5-IP 7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab, 3, 2021
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