5YZ3

Crystal structure of T2R-TTL-28 complex

Summary for 5YZ3

• Entry DOI: 10.2210/pdb5yz3/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-[4-(diethylamino)phenyl]-4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxamide, ... (15 entities in total)
• Functional Keywords: tubulin, complex, structural protein-inhibitor complex, structural protein, cell cycle
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 264974.89

Authors

Yu, Y.,Chen, Q. (deposition date: 2017-12-12, release date: 2018-10-24, Last modification date: 2023-11-22)

• Primary citation: Ning, N.,Yu, Y.,Wu, M.,Zhang, R.,Zhang, T.,Zhu, C.,Huang, L.,Yun, C.H.,Benes, C.H.,Zhang, J.,Deng, X.,Chen, Q.,Ren, R.; A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.; Cancer Res., 78:5949-5957, 2018; PubMed: 30135190; DOI: 10.1158/0008-5472.CAN-18-0455

Experimental method

X-RAY DIFFRACTION (2.545 Å)