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5TPC
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BU of 5tpc by Molmil
Binding domain of BoNT/A complexed with ganglioside
Descriptor: Botulinum neurotoxin type A, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose
Authors:Berntsson, R.P.-A, Svensson, L.M, Stenmark, P.
Deposit date:2016-10-20
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A.
J. Am. Chem. Soc., 139, 2017
2ANI
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BU of 2ani by Molmil
Crystal structure of the F127Y mutant of Ribonucleotide Reductase R2 from Chlamydia trachomatis
Descriptor: FE (III) ION, LEAD (II) ION, Ribonucleoside-diphosphate reductase beta subunit
Authors:Hogbom, M, Stenmark, P, Nordlund, P.
Deposit date:2005-08-11
Release date:2006-07-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the high-valent FeIIIFeIV state in ribonucleotide reductase (RNR) of Chlamydia trachomatis--combined EPR, 57Fe-, 1H-ENDOR and X-ray studies.
Biochim.Biophys.Acta, 1774, 2007
5LPG
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BU of 5lpg by Molmil
Structure of NUDT15 in complex with 6-thio-GMP
Descriptor: MAGNESIUM ION, Probable 8-oxo-dGTP diphosphatase NUDT15, [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-sulfanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate
Authors:Masuyer, G, Carter, M, Rehling, D, Stenmark, P, Helleday, T, Jemth, A.-S, Valerie, N.C.K, Homan, E, Herr, P, Bevc, L, Page, B.D.G, Hagenkort, A.
Deposit date:2016-08-12
Release date:2016-08-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Cancer Res., 76, 2016
5LOU
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BU of 5lou by Molmil
human NUDT22
Descriptor: Nucleoside diphosphate-linked moiety X motif 22, PHOSPHATE ION
Authors:Carter, M, Stenmark, P.
Deposit date:2016-08-10
Release date:2017-09-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Structure, 26, 2018
6G3Y
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BU of 6g3y by Molmil
Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH5675
Descriptor: 4-(4-azanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide, ACETATE ION, N-glycosylase/DNA lyase, ...
Authors:Masuyer, G, Helleday, T, Stenmark, P.
Deposit date:2018-03-26
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Science, 362, 2018
6G3X
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BU of 6g3x by Molmil
Native Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1
Descriptor: N-glycosylase/DNA lyase, NICKEL (II) ION
Authors:Masuyer, G, Helleday, T, Stenmark, P.
Deposit date:2018-03-26
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Science, 362, 2018
7ALE
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BU of 7ale by Molmil
Crystal structure of human PAICS in complex with inhibitor 69
Descriptor: (2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid, 2-azanyl-~{N}-[2-bromanyl-5-[4-[3-(dimethylamino)propylsulfonyl]piperazin-1-yl]phenyl]-1,3-oxazole-4-carboxamide, Multifunctional protein ADE2
Authors:Skerlova, J, Marttila, P, Unterlass, J, Jemth, A.-S, Henriksson, M, Wakchaure, P, Grube, M, Warpman Berglund, U, Homan, E, Helleday, T, Stenmark, P.
Deposit date:2020-10-06
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Cellular and biochemical validation of a potent PAICS inhibitor
To Be Published
7AIK
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BU of 7aik by Molmil
Ribonucleotide Reductase R2 protein from Aquifex aeolicus
Descriptor: FE (II) ION, Ribonucleoside-diphosphate reductase subunit beta,Ribonucleoside-diphosphate reductase subunit beta
Authors:Rehling, D, Scaletti, E.R, Stenmark, P.
Deposit date:2020-09-27
Release date:2021-11-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Biochemistry, 61, 2022
7NR6
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BU of 7nr6 by Molmil
Structure of NUDT15 in complex with NSC56456
Descriptor: 1,2-ETHANEDIOL, 2-azanyl-9-cyclohexyl-3~{H}-purine-6-thione, MAGNESIUM ION, ...
Authors:Rehling, D, Stenmark, P.
Deposit date:2021-03-03
Release date:2022-03-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Coupling cellular target engagement to drug-induced responses with CeTEAM
To Be Published
7OVW
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BU of 7ovw by Molmil
Binding domain of botulinum neurotoxin E in complex with GD1a
Descriptor: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-beta-D-galactopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, Neurotoxin type E
Authors:Masuyer, G, Stenmark, P.
Deposit date:2021-06-15
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.
Int J Mol Sci, 22, 2021
7P37
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BU of 7p37 by Molmil
Streptomyces coelicolor ATP-loaded NrdR
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ZINC ION
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2021-07-07
Release date:2022-05-11
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.
Nat Commun, 13, 2022
7P3Q
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BU of 7p3q by Molmil
Streptomyces coelicolor dATP/ATP-loaded NrdR octamer
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ...
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2021-07-08
Release date:2022-05-11
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.
Nat Commun, 13, 2022
7P3F
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BU of 7p3f by Molmil
Streptomyces coelicolor dATP/ATP-loaded NrdR in complex with its cognate DNA
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (50-MER), ...
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2021-07-07
Release date:2022-05-11
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.
Nat Commun, 13, 2022
8B5S
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BU of 8b5s by Molmil
Crystal Structure of P. aeruginosa WaaG in complex with UDP-glucose
Descriptor: UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-DIPHOSPHATE, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Scaletti, E, Gustafsson Westergren, R, Stenmark, P.
Deposit date:2022-09-24
Release date:2023-10-04
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
8B5Q
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BU of 8b5q by Molmil
Crystal Structure of P. aeruginosa WaaG in complex with UMP
Descriptor: UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-MONOPHOSPHATE
Authors:Scaletti, E, Gustafsson Westergren, R, Stenmark, P.
Deposit date:2022-09-24
Release date:2023-10-04
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
8B62
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BU of 8b62 by Molmil
Crystal Structure of P. aeruginosa WaaG in complex with UDP-galactose
Descriptor: GALACTOSE-URIDINE-5'-DIPHOSPHATE, GLYCEROL, UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG
Authors:Scaletti, E, Gustafsson Westergren, R, Stenmark, P.
Deposit date:2022-09-25
Release date:2023-10-04
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
8B63
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BU of 8b63 by Molmil
Crystal Structure of P. aeruginosa WaaG in complex with UDP-GalNAc
Descriptor: ACETATE ION, UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-DIPHOSPHATE, ...
Authors:Scaletti, E, Gustafsson Westergren, R, Stenmark, P.
Deposit date:2022-09-25
Release date:2023-10-04
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
7AYZ
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BU of 7ayz by Molmil
Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with activator TH10785
Descriptor: N-glycosylase/DNA lyase, NICKEL (II) ION, ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine
Authors:Masuyer, G, Davies, J.R, Stenmark, P.
Deposit date:2020-11-13
Release date:2022-06-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science, 376, 2022
7AYY
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BU of 7ayy by Molmil
Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, N-glycosylase/DNA lyase, ...
Authors:Masuyer, G, Davies, J.R, Stenmark, P.
Deposit date:2020-11-13
Release date:2022-06-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science, 376, 2022
7AZ0
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BU of 7az0 by Molmil
Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with TH12161
Descriptor: 2-cyclopropyl-~{N}-(4-iodophenyl)quinazolin-4-amine, N-glycosylase/DNA lyase, NICKEL (II) ION
Authors:Davies, J.R, Masuyer, G, Stenmark, P.
Deposit date:2020-11-13
Release date:2022-06-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science, 376, 2022
5LR0
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BU of 5lr0 by Molmil
Binding domain of Botulinum Neurotoxin DC in complex with SialylT
Descriptor: Botulinum neurotoxin D/C protein, N-acetyl-alpha-neuraminic acid, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose, ...
Authors:Berntsson, R.P.-A, Stenmark, P.
Deposit date:2016-08-18
Release date:2017-08-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.
Nat Commun, 8, 2017
5LV0
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BU of 5lv0 by Molmil
Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product
Descriptor: CHLORIDE ION, GLY-VAL-VAL amyloid 35-40 fragment, Neurolysin, ...
Authors:Masuyer, G, Berntsson, R.P.-A, Teixeira, P.F, Kmiec, B, Glaser, E, Stenmark, P.
Deposit date:2016-09-12
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional analysis of Neurolysin, a new component of the mitochondrial peptidolytic network
To Be Published
5LUZ
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BU of 5luz by Molmil
Structure of Human Neurolysin (E475Q) in complex with neurotensin peptide products
Descriptor: CHLORIDE ION, GLYCEROL, Neurolysin, ...
Authors:Masuyer, G, Berntsson, R.P.-A, Teixeira, P.F, Kmiec, B, Glaser, E, Stenmark, P.
Deposit date:2016-09-12
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.
J. Mol. Biol., 430, 2018
5LOR
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BU of 5lor by Molmil
human NUDT22
Descriptor: Nucleoside diphosphate-linked moiety X motif 22, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Carter, M, Stenmark, P.
Deposit date:2016-08-09
Release date:2017-08-16
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.192 Å)
Cite:Structural and functional studies of human NUDT22
To Be Published
4ISR
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BU of 4isr by Molmil
Binding domain of Botulinum neurotoxin DC in complex with rat synaptotagmin II
Descriptor: Neurotoxin, SULFATE ION, Synaptotagmin-2
Authors:Berntsson, R.P.-A, Peng, L, Svensson, L.M, Dong, M, Stenmark, P.
Deposit date:2013-01-17
Release date:2013-08-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II.
Structure, 21, 2013

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