5LR0

Binding domain of Botulinum Neurotoxin DC in complex with SialylT

Summary for 5LR0

• Entry DOI: 10.2210/pdb5lr0/pdb
• Related: 4ISQ 4ISR
• Descriptor: Botulinum neurotoxin D/C protein, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose, ... (5 entities in total)
• Functional Keywords: botulnimun neurotoxin, carbohydrate binding, hydrolase
• Biological source: Clostridium botulinum
• Total number of polymer chains: 2
• Total formula weight: 101497.98

Authors

Berntsson, R.P.-A.,Stenmark, P. (deposition date: 2016-08-18, release date: 2017-08-30, Last modification date: 2024-01-10)

• Primary citation: Zhang, S.,Berntsson, R.P.,Tepp, W.H.,Tao, L.,Johnson, E.A.,Stenmark, P.,Dong, M.; Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.; Nat Commun, 8:1637-1637, 2017; PubMed: 29158482; DOI: 10.1038/s41467-017-01534-z

Experimental method

X-RAY DIFFRACTION (2.59 Å)