5LR0

Binding domain of Botulinum Neurotoxin DC in complex with SialylT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Botulinum neurotoxin D/C protein	polymer	431	50065.4	2	UniProt (A5JGM8) Pfam (PF07953) Pfam (PF07951)	Clostridium botulinum	D/C mosaic neurotoxin,Neurotoxin,Neurotoxin type DC
2	C (C)	N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose	branched		674.6	1	In PDB GlyTouCan (G02684WR)
3	D (D)	beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose	branched		383.3	1	In PDB GlyTouCan (G01534TU)
4	E (B)	N-acetyl-alpha-neuraminic acid	non-polymer		309.3	1	Chemie (SIA)
5	F, G (A, B)	water	water		18.0	143	Chemie (HOH)

Sequence modifications

A, B: 863 - 1284 (UniProt: A5JGM8)

PDB	External Database	Details
Met 854	-	initiating methionine
His 855	-	expression tag
His 856	-	expression tag
His 857	-	expression tag
His 858	-	expression tag
His 859	-	expression tag
His 860	-	expression tag
Tyr 861	-	expression tag
Phe 862	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	100130.8
Branched	Number of molecules	2
	Total formula weight	1058.0
Non-Polymers*	Number of molecules	1
	Total formula weight	309.3
All*	Total formula weight	101498.0

*Water molecules are not included.