3DLN
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![BU of 3dln by Molmil](/molmil-images/mine/3dln) | Crystal structure of the binding domain of the AMPA subunit GluR3 bound to glutamate | Descriptor: | GLUTAMIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. | Deposit date: | 2008-06-27 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
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3H03
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![BU of 3h03 by Molmil](/molmil-images/mine/3h03) | |
3IL1
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![BU of 3il1 by Molmil](/molmil-images/mine/3il1) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 | Descriptor: | (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | Deposit date: | 2009-08-06 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3ILT
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![BU of 3ilt by Molmil](/molmil-images/mine/3ilt) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide | Descriptor: | 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | Deposit date: | 2009-08-07 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.107 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3IK6
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![BU of 3ik6 by Molmil](/molmil-images/mine/3ik6) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide | Descriptor: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | Deposit date: | 2009-08-05 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3H06
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![BU of 3h06 by Molmil](/molmil-images/mine/3h06) | |
3IJO
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![BU of 3ijo by Molmil](/molmil-images/mine/3ijo) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide | Descriptor: | (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | Deposit date: | 2009-08-04 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3IJX
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![BU of 3ijx by Molmil](/molmil-images/mine/3ijx) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide | Descriptor: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | Deposit date: | 2009-08-05 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.881 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3ILU
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![BU of 3ilu by Molmil](/molmil-images/mine/3ilu) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide | Descriptor: | 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | Deposit date: | 2009-08-07 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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1AJE
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![BU of 1aje by Molmil](/molmil-images/mine/1aje) | CDC42 FROM HUMAN, NMR, 20 STRUCTURES | Descriptor: | CDC42HS | Authors: | Feltham, J.L, Dotsch, V, Raza, S, Manor, D, Cerione, R.A, Sutcliffe, M.J, Wagner, G, Oswald, R.E. | Deposit date: | 1997-05-02 | Release date: | 1997-11-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Definition of the switch surface in the solution structure of Cdc42Hs. Biochemistry, 36, 1997
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2ASE
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![BU of 2ase by Molmil](/molmil-images/mine/2ase) | |
4F29
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![BU of 4f29 by Molmil](/molmil-images/mine/4f29) | Quisqualate bound to the ligand binding domain of GluA3i | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-07 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.749 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F2O
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![BU of 4f2o by Molmil](/molmil-images/mine/4f2o) | Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3 | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-08 | Release date: | 2012-05-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.912 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F3G
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![BU of 4f3g by Molmil](/molmil-images/mine/4f3g) | Kainate bound to the ligand binding domain of GluA3i | Descriptor: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-09 | Release date: | 2012-05-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.064 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F22
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![BU of 4f22 by Molmil](/molmil-images/mine/4f22) | |
4GXS
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![BU of 4gxs by Molmil](/molmil-images/mine/4gxs) | Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin | Descriptor: | (5R)-2-[(1S,2R)-2-amino-2-carboxy-1-hydroxyethyl]-5-{(2S)-2-carboxy-2-[(3,5-dichloro-4-hydroxybenzoyl)amino]ethyl}-L-proline, Glutamate receptor 2, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-09-04 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9634 Å) | Cite: | The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2. J.Biol.Chem., 287, 2012
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4F1Y
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![BU of 4f1y by Molmil](/molmil-images/mine/4f1y) | CNQX bound to the ligand binding domain of GluA3 | Descriptor: | 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-07 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F2Q
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![BU of 4f2q by Molmil](/molmil-images/mine/4f2q) | Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3 | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-08 | Release date: | 2012-05-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F3B
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![BU of 4f3b by Molmil](/molmil-images/mine/4f3b) | |
4F31
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![BU of 4f31 by Molmil](/molmil-images/mine/4f31) | |
4F39
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![BU of 4f39 by Molmil](/molmil-images/mine/4f39) | Kainate bound to the ligand binding domain of GluA3 | Descriptor: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 3, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2012-05-09 | Release date: | 2012-05-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.834 Å) | Cite: | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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2KB0
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![BU of 2kb0 by Molmil](/molmil-images/mine/2kb0) | Cdc42(T35A) | Descriptor: | Cell division control protein 42 homolog | Authors: | Adams, P.D, Oswald, R.E, McFeeters, R. | Deposit date: | 2008-11-18 | Release date: | 2009-12-01 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Cdc42(T35A) To be Published
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5ELV
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![BU of 5elv by Molmil](/molmil-images/mine/5elv) | Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504-N775) in complex with glutamate and BPAM-521 at 1.92 A resolution | Descriptor: | 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, CHLORIDE ION, ... | Authors: | Krintel, C, Juknaite, L, Frydenvang, K, Kastrup, J.S. | Deposit date: | 2015-11-05 | Release date: | 2016-05-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. Biophys.J., 110, 2016
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5BUU
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![BU of 5buu by Molmil](/molmil-images/mine/5buu) | Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution | Descriptor: | (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, 1,2-ETHANEDIOL, GLUTAMIC ACID, ... | Authors: | Larsen, A.P, Tapken, D, Frydenvang, K, Kastrup, J.S. | Deposit date: | 2015-06-04 | Release date: | 2016-02-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. Acs Chem Neurosci, 7, 2016
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5O9A
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![BU of 5o9a by Molmil](/molmil-images/mine/5o9a) | Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution | Descriptor: | 1,2-ETHANEDIOL, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, ... | Authors: | Laulumaa, S, Rovinskaja, K, Frydenvang, K.A, Kastrup, J.S. | Deposit date: | 2017-06-16 | Release date: | 2018-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. J. Med. Chem., 61, 2018
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