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3IJX

Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide

Summary for 3IJX
Entry DOI10.2210/pdb3ijx/pdb
Related3IJO 3IK6 3IL1 3ILT 3ILU
DescriptorGlutamate receptor 2, GLUTAMIC ACID, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ... (5 entities in total)
Functional Keywordsglutamate receptor, glur2, ampa receptor, neurotransmitter receptor, s1s2, allosteric modulator, membrane protein
Biological sourceRattus norvegicus (rat)
More
Cellular locationCell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains3
Total formula weight88086.54
Authors
Ptak, C.P.,Ahmed, A.H.,Oswald, R.E. (deposition date: 2009-08-05, release date: 2009-09-15, Last modification date: 2023-09-06)
Primary citationPtak, C.P.,Ahmed, A.H.,Oswald, R.E.
Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48:8594-8602, 2009
Cited by
PubMed: 19673491
DOI: 10.1021/bi901127s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.881 Å)
Structure validation

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