3ILU

Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide

Summary for 3ILU

Entry DOI	10.2210/pdb3ilu/pdb
Related	3IJO 3IJX 3IK6 3IL1 3ILT
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ... (5 entities in total)
Functional Keywords	glutamate receptor, glur2, ampa receptor, neurotransmitter receptor, s1s2, allosteric modulator, membrane protein
Biological source	Rattus norvegicus (rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	3
Total formula weight	88187.20
Authors	Ahmed, A.H.,Ptak, C.P.,Oswald, R.E. (deposition date: 2009-08-07, release date: 2009-09-15, Last modification date: 2023-09-06)
Primary citation	Ptak, C.P.,Ahmed, A.H.,Oswald, R.E. Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48:8594-8602, 2009 Cited by PubMed: 19673491 DOI: 10.1021/bi901127s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.003 Å)

Structure validation