3ILU

Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HFZ B 800

Chain	Residue
B	LYS104
E	PRO105
E	SER108
E	SER217
E	LYS218
E	GLY219
E	HOH331
E	HFZ800
B	PRO105
B	PHE106
B	MET107
B	SER108
B	LEU239
B	SER242
B	HOH379
E	ILE92

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 262

Chain	Residue
B	GLU42
B	HIS46
H	GLU166

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HFZ E 800

Chain	Residue
B	ILE92
B	PRO105
B	SER108
B	SER217
B	LYS218
B	GLY219
B	HOH305
B	HFZ800
E	LYS104
E	PRO105
E	MET107
E	SER108
E	LEU239
E	SER242
E	HOH444
E	HOH554

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
B	HIS23
E	ASP65
E	ASP67

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN E 3

Chain	Residue
E	GLU42
E	HIS46
E	HOH422

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 262

Chain	Residue
E	HIS23
E	GLU24
H	HIS23
H	GLU30

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HFZ H 800

Chain	Residue
H	ILE92
H	LYS104
H	PRO105
H	PRO105
H	PHE106
H	MET107
H	SER108
H	SER108
H	SER217
H	LYS218
H	GLY219
H	LEU239
H	SER242
H	HOH384

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 2

Chain	Residue
B	GLU166
H	GLU42
H	HIS46
H	GLN244

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
B	PRO89
E	SER142
E	THR143
E	GLU193
H	PRO89
H	THR91
H	ARG96
H	SER142
H	THR143
H	GLU193
B	THR91
B	ARG96
B	SER142
B	THR143
B	GLU193
E	PRO89
E	THR91
E	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG64
B	ARG148
B	LYS240
E	ARG64
E	ARG148
E	LYS240
H	ARG64
H	ARG148
H	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE121
E	ILE121
H	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER150
E	SER150
H	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER184
E	SER184
H	SER184

---