3IJO

Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide

Summary for 3IJO

Entry DOI	10.2210/pdb3ijo/pdb
Related	3IJX 3IK6 3IL1 3ILT 3ILU
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ... (5 entities in total)
Functional Keywords	glutamate receptor, glur2, ampa receptor, neurotransmitter receptor, s1s2, allosteric modulator, alternative splicing, cell junction, cell membrane, endoplasmic reticulum, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphoprotein, postsynaptic cell membrane, receptor, rna editing, synapse, transmembrane, transport, membrane protein
Biological source	Rattus norvegicus (rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	3
Total formula weight	88345.01
Authors	Ptak, C.P.,Ahmed, A.H.,Oswald, R.E. (deposition date: 2009-08-04, release date: 2009-09-15, Last modification date: 2023-09-06)
Primary citation	Ptak, C.P.,Ahmed, A.H.,Oswald, R.E. Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48:8594-8602, 2009 Cited by PubMed: 19673491 DOI: 10.1021/bi901127s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.003 Å)

Structure validation