3IJX

Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 400

Chain	Residue
B	TYR61
B	GLU193
B	HOH263
B	HOH266
B	HOH302
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GLU D 400

Chain	Residue
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	LEU138
D	GLY141
D	SER142
D	THR143
D	GLU193
D	HOH266

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GLU H 400

Chain	Residue
H	TYR61
H	PRO89
H	LEU90
H	THR91
H	ARG96
H	LEU138
H	GLY141
H	SER142
H	THR143
H	GLU193

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HCZ B 800

Chain	Residue
B	LYS104
B	PRO105
B	SER108
B	LEU239
B	SER242
D	ILE92
D	SER108
D	SER217
D	LYS218
D	GLY219
D	HCZ800

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HCZ D 800

Chain	Residue
B	ILE92
B	SER108
B	SER217
B	LYS218
B	HCZ800
D	LYS104
D	PRO105
D	SER108
D	LEU239
D	SER242

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HCZ H 800

Chain	Residue
H	ILE92
H	LYS104
H	PRO105
H	SER108
H	SER108
H	SER217
H	LYS218
H	LEU239
H	SER242
H	HOH313

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 1

Chain	Residue
D	GLU42
D	HIS46

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN H 2

Chain	Residue
H	ZN3
H	GLU166

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 3

Chain	Residue
B	GLU42
B	HIS46
H	ZN2
H	GLU166

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 262

Chain	Residue
B	HIS23
D	ASP65
D	ASP67

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN H 262

Chain	Residue
H	GLU42
H	HIS46
H	LEU241

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
B	PRO89
D	SER142
D	THR143
D	GLU193
H	PRO89
H	THR91
H	ARG96
H	SER142
H	THR143
H	GLU193
B	THR91
B	ARG96
B	SER142
B	THR143
B	GLU193
D	PRO89
D	THR91
D	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG64
B	ARG148
B	LYS240
D	ARG64
D	ARG148
D	LYS240
H	ARG64
H	ARG148
H	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE121
D	ILE121
H	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER150
D	SER150
H	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER184
D	SER184
H	SER184

---