5BUU

Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution

Summary for 5BUU

• Entry DOI: 10.2210/pdb5buu/pdb
• Related: 3il1 4n07
• Descriptor: Glutamate receptor 2,Glutamate receptor 2, (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, ... (6 entities in total)
• Functional Keywords: ampa receptor ligand-binding domain, glua2 l483y-n754s, bpam-321 positive allosteric modulation, membrane protein
• Biological source: Rattus norvegicus (Norway Rat); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P19491
• Total number of polymer chains: 2
• Total formula weight: 60095.75

Authors

Larsen, A.P.,Tapken, D.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2015-06-04, release date: 2016-02-17, Last modification date: 2024-01-10)

• Primary citation: Larsen, A.P.,Francotte, P.,Frydenvang, K.,Tapken, D.,Goffin, E.,Fraikin, P.,Caignard, D.H.,Lestage, P.,Danober, L.,Pirotte, B.,Kastrup, J.S.; Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.; Acs Chem Neurosci, 7:378-390, 2016; PubMed: 26771108; DOI: 10.1021/acschemneuro.5b00318

Experimental method

X-RAY DIFFRACTION (2.07 Å)