5BUU
Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 4V6 A 801 |
| Chain | Residue |
| A | ILE481 |
| B | 4V6801 |
| A | SER497 |
| A | LYS730 |
| A | GLY731 |
| A | SO4805 |
| B | LYS493 |
| B | PRO494 |
| B | SER497 |
| B | SER754 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue GLU A 802 |
| Chain | Residue |
| A | TYR450 |
| A | PRO478 |
| A | LEU479 |
| A | THR480 |
| A | ARG485 |
| A | GLY653 |
| A | SER654 |
| A | THR655 |
| A | GLU705 |
| A | HOH923 |
| A | HOH938 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | SER652 |
| A | LYS656 |
| A | ARG660 |
| A | HOH905 |
| A | HOH909 |
| A | HOH911 |
| A | HOH961 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 804 |
| Chain | Residue |
| A | PRO494 |
| A | LEU751 |
| A | HOH903 |
| B | LYS730 |
| B | GLY731 |
| B | 4V6801 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 805 |
| Chain | Residue |
| A | LYS730 |
| A | GLY731 |
| A | 4V6801 |
| B | LYS493 |
| B | PRO494 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue 4V6 B 801 |
| Chain | Residue |
| A | LYS493 |
| A | PRO494 |
| A | SER497 |
| A | LEU751 |
| A | SER754 |
| A | 4V6801 |
| A | SO4804 |
| A | HOH903 |
| B | ILE481 |
| B | SER497 |
| B | LYS730 |
| B | GLY731 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue GLU B 802 |
| Chain | Residue |
| B | TYR450 |
| B | PRO478 |
| B | LEU479 |
| B | THR480 |
| B | ARG485 |
| B | GLY653 |
| B | SER654 |
| B | THR655 |
| B | GLU705 |
| B | HOH911 |
| B | HOH919 |
| B | HOH922 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 803 |
| Chain | Residue |
| B | ALA452 |
| B | SER652 |
| B | LYS656 |
| B | ARG660 |
| B | HOH902 |
| B | HOH908 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 804 |
| Chain | Residue |
| A | LYS695 |
| B | ARG420 |
| B | HOH907 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 805 |
| Chain | Residue |
| A | TYR483 |
| B | HIS435 |
| B | ALA745 |
| B | LEU748 |
| B | ALA749 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 806 |
| Chain | Residue |
| A | ASN726 |
| A | SER729 |
| B | ASP760 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 807 |
| Chain | Residue |
| A | LYS493 |
| B | GLU486 |
| B | ASP490 |
| B | PHE491 |
| B | HOH913 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 808 |
| Chain | Residue |
| A | ASP760 |
| B | ASP728 |
| B | SER729 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 809 |
| Chain | Residue |
| B | ARG660 |
| B | TRP671 |
| B | ARG675 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
