5BUU
Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor 2,Glutamate receptor 2 | polymer | 263 | 29244.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | C, H (A, B) | (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 260.7 | 2 | Chemie (4V6) | |||
| 3 | D, I (A, B) | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) | |||
| 4 | E, F, G, J, K (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | L, M, N, O, P (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | Q, R (A, B) | water | water | 18.0 | 275 | Chemie (HOH) |
Sequence modifications
A, B: 392 - 506 (UniProt: P19491)
A, B: 632 - 775 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 390 | - | expression tag |
| Ala 391 | - | expression tag |
| Tyr 483 | Leu 504 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 507 | - | linker |
| Thr 508 | - | linker |
| Ser 754 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58489.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1606.4 | |
| All* | Total formula weight | 60095.7 |
