3H06
Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282
Summary for 3H06
Entry DOI | 10.2210/pdb3h06/pdb |
Related | 3H03 |
Descriptor | Glutamate receptor 2, 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid (3 entities in total) |
Functional Keywords | glutamate receptor, glur2, ampa receptor, neurotransmitter receptor, s1s2, willardiine, membrane protein |
Biological source | Rattus norvegicus More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 8 |
Total formula weight | 233348.93 |
Authors | Ahmed, A.H.,Oswald, R.E. (deposition date: 2009-04-08, release date: 2009-05-05, Last modification date: 2017-08-23) |
Primary citation | Ahmed, A.H.,Thompson, M.D.,Fenwick, M.K.,Romero, B.,Loh, A.P.,Jane, D.E.,Sondermann, H.,Oswald, R.E. Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 48:3894-3903, 2009 Cited by PubMed: 19284741DOI: 10.1021/bi900107m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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