3H06

Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
G	0015276	molecular_function	ligand-gated monoatomic ion channel activity
G	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane
J	0015276	molecular_function	ligand-gated monoatomic ion channel activity
J	0016020	cellular_component	membrane
L	0015276	molecular_function	ligand-gated monoatomic ion channel activity
L	0016020	cellular_component	membrane
N	0015276	molecular_function	ligand-gated monoatomic ion channel activity
N	0016020	cellular_component	membrane
P	0015276	molecular_function	ligand-gated monoatomic ion channel activity
P	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE VBP G 803

Chain	Residue
G	TYR61
G	HOH264
G	HOH273
G	HOH274
G	PRO89
G	THR91
G	ARG96
G	LEU138
G	THR143
G	GLU193
G	MET196
G	TYR220

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE VBP B 807

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	THR143
B	THR174
B	LEU192
B	GLU193
B	TYR220
B	HOH296

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE VBP E 808

Chain	Residue
E	TYR16
E	TYR61
E	PRO89
E	LEU90
E	THR91
E	ARG96
E	LEU138
E	THR143
E	THR174
E	TYR190
E	GLU193
E	MET196
E	TYR220
E	HOH279

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE VBP H 806

Chain	Residue
H	GLU13
H	TYR16
H	TYR61
H	PRO89
H	THR91
H	ARG96
H	LEU138
H	THR143
H	THR174
H	GLU193
H	MET196
H	TYR220
H	HOH279

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE VBP J 804

Chain	Residue
J	HOH3
J	TYR61
J	PRO89
J	LEU90
J	THR91
J	ARG96
J	LEU138
J	THR143
J	LEU192
J	GLU193
J	MET196
J	HOH273

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE VBP L 801

Chain	Residue
L	TYR16
L	TYR61
L	PRO89
L	LEU90
L	THR91
L	ARG96
L	LEU138
L	THR143
L	THR174
L	TYR190
L	LEU192
L	GLU193
L	MET196
L	TYR220
L	HOH262
L	HOH265
L	HOH287

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE VBP N 802

Chain	Residue
N	GLU13
N	TYR61
N	PRO89
N	THR91
N	ARG96
N	THR143
N	THR174
N	LEU192
N	GLU193
N	MET196
N	TYR220
N	HOH266
N	HOH273
N	HOH292

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE VBP P 805

Chain	Residue
P	LEU138
P	THR143
P	THR174
P	TYR190
P	LEU191
P	LEU192
P	GLU193
P	MET196
P	HOH270
P	TYR61
P	PRO89
P	LEU90
P	THR91
P	ARG96

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
G	PRO89
B	SER142
B	THR143
B	GLU193
E	PRO89
E	THR91
E	ARG96
E	SER142
E	THR143
E	GLU193
H	PRO89
G	THR91
H	THR91
H	ARG96
H	SER142
H	THR143
H	GLU193
J	PRO89
J	THR91
J	ARG96
J	SER142
J	THR143
G	ARG96
J	GLU193
L	PRO89
L	THR91
L	ARG96
L	SER142
L	THR143
L	GLU193
N	PRO89
N	THR91
N	ARG96
G	SER142
N	SER142
N	THR143
N	GLU193
P	PRO89
P	THR91
P	ARG96
P	SER142
P	THR143
P	GLU193
G	THR143
G	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
G	ARG64
H	ARG64
H	ARG148
H	LYS240
J	ARG64
J	ARG148
J	LYS240
L	ARG64
L	ARG148
L	LYS240
N	ARG64
G	ARG148
N	ARG148
N	LYS240
P	ARG64
P	ARG148
P	LYS240
G	LYS240
B	ARG64
B	ARG148
B	LYS240
E	ARG64
E	ARG148
E	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
G	ILE121
B	ILE121
E	ILE121
H	ILE121
J	ILE121
L	ILE121
N	ILE121
P	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
G	SER150
B	SER150
E	SER150
H	SER150
J	SER150
L	SER150
N	SER150
P	SER150

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
G	SER184
B	SER184
E	SER184
H	SER184
J	SER184
L	SER184
N	SER184
P	SER184

---