8E99
| Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2022-08-26 | Release date: | 2022-12-07 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (4.24 Å) | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82, 2022
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2QTS
| Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ... | Authors: | Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E. | Deposit date: | 2007-08-02 | Release date: | 2007-09-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH Nature, 449, 2007
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7TE9
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7TEQ
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7TES
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7TE4
| Crystal structure of Fab2 anti-GluN2B antibody | Descriptor: | Fab anti-GluN2B antibody, heavy chain, Fab2 anti-GluN2B antibody, ... | Authors: | Tajima, N, Furukawa, H. | Deposit date: | 2022-01-04 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.456 Å) | Cite: | Development and characterization of functional antibodies targeting NMDA receptors. Nat Commun, 13, 2022
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7TET
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7TE6
| Crystal structure of GluN1b-2B ATD complexed to Fab5 anti-GluN2B antibody | Descriptor: | Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ... | Authors: | Regan, M, Tajima, N, Furukawa, H. | Deposit date: | 2022-01-04 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (4.55 Å) | Cite: | Development and characterization of functional antibodies targeting NMDA receptors. Nat Commun, 13, 2022
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7TEE
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7TEB
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7TER
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8G18
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8GMR
| Cryo-EM structure of octameric human CALHM1 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1 | Authors: | Syrjanen, J.L, Furukawa, H. | Deposit date: | 2023-03-27 | Release date: | 2023-07-26 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red. Nat Commun, 14, 2023
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8GMQ
| Chicken CALHM1 purified from mammalian cells | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator 1 | Authors: | Syrjanen, J.L, Furukawa, H. | Deposit date: | 2023-03-27 | Release date: | 2023-07-26 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red. Nat Commun, 14, 2023
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8GMP
| Cryo-EM structure of octameric human CALHM1 with a I109W point mutation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1 | Authors: | Syrjanen, J.L, Furukawa, H. | Deposit date: | 2023-03-27 | Release date: | 2023-07-26 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red. Nat Commun, 14, 2023
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7SAB
| Phencyclidine-bound GluN1a-GluN2B NMDA receptors | Descriptor: | 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2021-09-22 | Release date: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7SAD
| Memantine-bound GluN1a-GluN2B NMDA receptors | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2021-09-22 | Release date: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7SAC
| S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution | Descriptor: | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2021-09-22 | Release date: | 2022-07-20 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7SAA
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4JWY
| GluN2D ligand-binding core in complex with propyl-NHP5G | Descriptor: | (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, Glutamate receptor ionotropic, NMDA 2D | Authors: | Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F. | Deposit date: | 2013-03-27 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors. Mol.Pharmacol., 84, 2013
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4JWX
| GluN2A ligand-binding core in complex with propyl-NHP5G | Descriptor: | (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, GluN2A | Authors: | Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F. | Deposit date: | 2013-03-27 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors. Mol.Pharmacol., 84, 2013
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6E7W
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6E7U
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6E7S
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6E7V
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