5KE9
| mouse Klf4 E446P ZnF1-3 and TpG/CpA sequence DNA complex structure | Descriptor: | DNA (5'-D(*GP*AP*GP*GP*TP*GP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*CP*AP*CP*CP*TP*C)-3'), Krueppel-like factor 4, ... | Authors: | Hashimoto, H, Cheng, X. | Deposit date: | 2016-06-09 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.336 Å) | Cite: | Distinctive Klf4 mutants determine preference for DNA methylation status. Nucleic Acids Res., 44, 2016
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5KEA
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5KL6
| Wilms Tumor Protein (WT1) Q369R ZnF2-4 in complex with DNA | Descriptor: | DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*CP*CP*AP*CP*GP*C)-3'), Wilms tumor protein, ... | Authors: | Hashimoto, H, Cheng, X. | Deposit date: | 2016-06-23 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.641 Å) | Cite: | Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res., 44, 2016
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5KL4
| Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with formylated DNA | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5FC)P*GP*T)-3'), ... | Authors: | Hashimoto, H, Cheng, X. | Deposit date: | 2016-06-23 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.783 Å) | Cite: | Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res., 44, 2016
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5KKQ
| Homo sapiens CCCTC-binding factor (CTCF) ZnF3-7 and DNA complex structure | Descriptor: | DNA (5'-D(*GP*CP*CP*AP*GP*CP*AP*GP*GP*GP*GP*GP*CP*GP*CP*TP*A)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*CP*CP*CP*CP*CP*TP*GP*CP*TP*GP*GP*C)-3'), Transcriptional repressor CTCF, ... | Authors: | Hashimoto, H, Wang, D, Cheng, X. | Deposit date: | 2016-06-22 | Release date: | 2017-05-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.744 Å) | Cite: | Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol. Cell, 66, 2017
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5KL5
| Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with carboxylated DNA | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(1CC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... | Authors: | Hashimoto, H, Cheng, X. | Deposit date: | 2016-06-23 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.289 Å) | Cite: | Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res., 44, 2016
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5KL2
| Wilms Tumor Protein (WT1) ZnF2-4 in complex with DNA | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*AP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*TP*CP*CP*CP*AP*CP*GP*C)-3'), ... | Authors: | Hashimoto, H, Cheng, X. | Deposit date: | 2016-06-23 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.692 Å) | Cite: | Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res., 44, 2016
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7VKM
| Crystal structure of TrkA (G595R) kinase domain | Descriptor: | Tyrosine-protein kinase receptor | Authors: | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | Deposit date: | 2021-09-30 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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7VKO
| Crystal structure of TrkA kinase with repotrectinib | Descriptor: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | Authors: | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | Deposit date: | 2021-09-30 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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7VKN
| Crystal structure of TrkA (G595R) kinase with repotrectinib | Descriptor: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | Authors: | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | Deposit date: | 2021-09-30 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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5Z9X
| Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 in complex with an RNA substrate | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*GP*CP*CP*CP*AP*UP*UP*AP*G)-3'), SULFATE ION, ... | Authors: | Chen, J, Liu, L, You, C, Gu, J, Ruan, W, Zhang, L, Gan, J, Cao, C, Huang, Y, Chen, X, Ma, J. | Deposit date: | 2018-02-05 | Release date: | 2018-06-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun, 9, 2018
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5Z9Z
| The C-terminal RRM domain of Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 (E329A/E330A/E332A) | Descriptor: | CITRATE ANION, Small RNA degrading nuclease 1 | Authors: | Chen, J, Liu, L, You, C, Gu, J, Ruan, W, Zhang, L, Cao, C, Gan, J, Huang, Y, Chen, X, Ma, J. | Deposit date: | 2018-02-05 | Release date: | 2018-06-27 | Last modified: | 2018-10-03 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun, 9, 2018
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6IZJ
| Structural characterization of mutated NreA protein in nitrate binding site from Staphylococcus aureus | Descriptor: | 1,2-ETHANEDIOL, NITRATE ION, NreA | Authors: | Sangare, L, Chen, W, Wang, C, Chen, X, Wu, M, Zhang, X, Zang, J. | Deposit date: | 2018-12-19 | Release date: | 2020-01-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the conformational change of Staphylococcus aureus NreA at C-terminus. Biotechnol.Lett., 42, 2020
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6K2H
| structural characterization of mutated NreA protein in nitrate binding site from staphylococcus aureus. | Descriptor: | 1,2-ETHANEDIOL, NreA | Authors: | Sangare, L, Chen, W, Wang, C, Chen, X, Wu, M, Zhang, X, Zang, J. | Deposit date: | 2019-05-14 | Release date: | 2020-03-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural insights into the conformational change of Staphylococcus aureus NreA at C-terminus. Biotechnol.Lett., 42, 2020
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8JQK
| Crystal structure of a carbonyl reductase SSCR mutant from Sporobolomyces Salmonicolor | Descriptor: | Aldehyde reductase 2 | Authors: | Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M. | Deposit date: | 2023-06-14 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer Acs Catalysis, 13, 2023
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8JQJ
| Crystal structure of carbonyl reductase SSCR mutant 1 from Sporobolomyces Salmonicolor | Descriptor: | Aldehyde reductase 2 | Authors: | Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M. | Deposit date: | 2023-06-14 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer Acs Catalysis, 13, 2023
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6JPJ
| Crystal structure of FGF401 in complex of FGFR4 | Descriptor: | Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION | Authors: | Zhou, Z, Chen, X, Chen, Y. | Deposit date: | 2019-03-27 | Release date: | 2019-05-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.638 Å) | Cite: | Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4. Chem.Commun.(Camb.), 55, 2019
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8H8Y
| Crystal structure of AbHheG from Acidimicrobiia bacterium | Descriptor: | GLYCEROL, alpha/beta hydrolase | Authors: | Zhou, C.H, Chen, X, Han, X, Liu, W.D, Wu, Q.Q, Zhu, D.M, Ma, Y.H. | Deposit date: | 2022-10-24 | Release date: | 2023-08-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Flipping the Substrate Creates a Highly Selective Halohydrin Dehalogenase for the Synthesis of Chiral 4-Aryl-2-oxazolidinones from Readily Available Epoxides Acs Catalysis, 13, 2023
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8HQP
| Crystal structure of AbHheG mutant from Acidimicrobiia bacterium | Descriptor: | AbHheG_m | Authors: | Zhou, C.H, Chen, X, Han, X, Liu, W.D, Wu, Q.Q, Zhu, D.M, Ma, Y.H. | Deposit date: | 2022-12-13 | Release date: | 2023-08-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Flipping the Substrate Creates a Highly Selective Halohydrin Dehalogenase for the Synthesis of Chiral 4-Aryl-2-oxazolidinones from Readily Available Epoxides Acs Catalysis, 13, 2023
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7VI6
| Crystal structure of GH3 beta-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila | Descriptor: | Beta-N-acetylhexosaminidase, CHLORIDE ION, MAGNESIUM ION | Authors: | Qian, K, Yang, W, Chen, X, Wang, Y, Zhang, M, Wang, M. | Deposit date: | 2021-09-26 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Functional and structural characterization of a GH3 beta-N-acetylhexosaminidase from Akkermansia muciniphila involved in mucin degradation Biochem.Biophys.Res.Commun., 589, 2022
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7VI7
| Crystal structure of GH3 beta-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila in complex with GlcNAc | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | Authors: | Qian, K, Yang, W, Chen, X, Wang, Y, Zhang, M, Wang, M. | Deposit date: | 2021-09-26 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Functional and structural characterization of a GH3 beta-N-acetylhexosaminidase from Akkermansia muciniphila involved in mucin degradation Biochem.Biophys.Res.Commun., 589, 2022
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5ZE2
| Hairpin Complex, RAG1/2-hairpin 12RSS/23RSS complex in 5mM Mn2+ for 2 min at 4'C | Descriptor: | 1,2-ETHANEDIOL, DNA (30-MER), DNA (31-MER), ... | Authors: | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | Deposit date: | 2018-02-25 | Release date: | 2018-04-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Cracking the DNA Code for V(D)J Recombination Mol. Cell, 70, 2018
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5ZDZ
| Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in Ca2+ | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (30-MER), ... | Authors: | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | Deposit date: | 2018-02-25 | Release date: | 2018-04-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Cracking the DNA Code for V(D)J Recombination Mol. Cell, 70, 2018
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5ZE0
| Hairpin Forming Complex, RAG1/2-Nicked(with Dideoxy) 12RSS/23RSS complex in Mg2+ | Descriptor: | 1,2-ETHANEDIOL, DNA (30-MER), DNA (39-MER), ... | Authors: | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | Deposit date: | 2018-02-25 | Release date: | 2018-04-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Cracking the DNA Code for V(D)J Recombination Mol. Cell, 70, 2018
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5ZE1
| Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in 2mM Mn2+ for 10 min at 4'C | Descriptor: | 1,2-ETHANEDIOL, DNA, HMGB1 A-B box, ... | Authors: | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | Deposit date: | 2018-02-25 | Release date: | 2018-04-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Cracking the DNA Code for V(D)J Recombination Mol. Cell, 70, 2018
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