7VKO

Crystal structure of TrkA kinase with repotrectinib

Summary for 7VKO

Entry DOI	10.2210/pdb7vko/pdb
Descriptor	Tyrosine-protein kinase receptor, Repotrectinib, SULFATE ION, ... (4 entities in total)
Functional Keywords	trk, ntrk, macrocyclic inhibitor, drug resistance, repotrectinib, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	38071.46
Authors	Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A. (deposition date: 2021-09-30, release date: 2021-10-13, Last modification date: 2023-11-29)
Primary citation	Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A. Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20:2446-2456, 2021 Cited by PubMed: 34625502 DOI: 10.1158/1535-7163.MCT-21-0632 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation