4DCN
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![BU of 4dcn by Molmil](/molmil-images/mine/4dcn) | Crystal Structure Analysis of the Arfaptin2 BAR domain in Complex with ARL1 | Descriptor: | ADP-ribosylation factor-like protein 1, Arfaptin-2, MAGNESIUM ION, ... | Authors: | Nakamura, K, Xie, Y, Kawasaki, M, Kato, R, Wakatsuki, S. | Deposit date: | 2012-01-18 | Release date: | 2012-06-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase J.Biol.Chem., 287, 2012
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1WQS
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![BU of 1wqs by Molmil](/molmil-images/mine/1wqs) | Crystal structure of Norovirus 3C-like protease | Descriptor: | 3C-like protease, D(-)-TARTARIC ACID, L(+)-TARTARIC ACID, ... | Authors: | Nakamura, K, Someya, Y, Kumasaka, T, Tanaka, N. | Deposit date: | 2004-10-01 | Release date: | 2005-10-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A norovirus protease structure provides insights into active and substrate binding site integrity J.Virol., 79, 2005
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7XY8
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![BU of 7xy8 by Molmil](/molmil-images/mine/7xy8) | Crystal structure of antibody Fab fragment in complex with CD147(EMMPIRIN) | Descriptor: | Isoform 2 of Basigin, heavy chain, light chain | Authors: | Nakamura, K, Amano, M, Yoneda, K, Suzuki, M, Fukuchi, K. | Deposit date: | 2022-06-01 | Release date: | 2022-11-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals. J Oncol, 2022, 2022
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7YRU
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![BU of 7yru by Molmil](/molmil-images/mine/7yru) | ALK2 antibody complex | Descriptor: | Activin receptor type-1, antibody heavy chain, antibody light chain | Authors: | Kawaguchi, Y, Nakamura, K, Suzuki, M, Tsuji, S, Katagiri, T. | Deposit date: | 2022-08-10 | Release date: | 2023-05-17 | Last modified: | 2023-06-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders. Nat Commun, 14, 2023
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1EW0
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![BU of 1ew0 by Molmil](/molmil-images/mine/1ew0) | CRYSTAL STRUCTURE ANALYSIS OF THE SENSOR DOMAIN OF RMFIXL(FERROUS FORM) | Descriptor: | FIXL, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Miyatake, H, Mukai, M, Park, S.-Y, Adachi, S, Tamura, K, Nakamura, H, Nakamura, K, Tsuchiya, T, Iizuka, T, Shiro, Y. | Deposit date: | 2000-04-21 | Release date: | 2000-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Sensory mechanism of oxygen sensor FixL from Rhizobium meliloti: crystallographic, mutagenesis and resonance Raman spectroscopic studies J.MOL.BIOL., 301, 2000
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3HSB
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![BU of 3hsb by Molmil](/molmil-images/mine/3hsb) | Crystal structure of YmaH (Hfq) from Bacillus subtilis in complex with an RNA aptamer | Descriptor: | Protein hfq, RNA (5'-R(*AP*GP*AP*GP*AP*GP*A)-3') | Authors: | Baba, S, Someya, T, Kumasaka, T, Kawai, G, Nakamura, K. | Deposit date: | 2009-06-10 | Release date: | 2010-06-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Hfq from Bacillus subtilis in complex with SELEX-derived RNA aptamer: insight into RNA-binding properties of bacterial Hfq Nucleic Acids Res., 40, 2012
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1D06
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![BU of 1d06 by Molmil](/molmil-images/mine/1d06) | STRUCTURAL BASIS OF DIMERIZATION AND SENSORY MECHANISMS OF OXYGEN-SENSING DOMAIN OF RHIZOBIUM MELILOTI FIXL DETERMINED AT 1.4A RESOLUTION | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, nitrogen fixation regulatory protein fixL | Authors: | Miyatake, H, Mukai, M, Park, S.-Y, Adachi, S, Tamura, K, Nakamura, H, Nakamura, K, Tsuchiya, T, Iizuka, T, Shiro, Y. | Deposit date: | 1999-09-09 | Release date: | 2000-03-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Sensory mechanism of oxygen sensor FixL from Rhizobium meliloti: crystallographic, mutagenesis and resonance Raman spectroscopic studies J.MOL.BIOL., 301, 2000
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3VW8
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![BU of 3vw8 by Molmil](/molmil-images/mine/3vw8) | Crystal structure of human c-Met kinase domain with its inhibitor | Descriptor: | CHLORIDE ION, Hepatocyte growth factor receptor, N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide | Authors: | Matsumoto, S, Miyamoto, N, Hirayama, T, Oki, H, Okada, K, Tawada, M, Iwata, H, Miki, H, Nakamura, K, Hori, A, Imamura, S. | Deposit date: | 2012-08-08 | Release date: | 2013-08-14 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors. Bioorg.Med.Chem., 21, 2013
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1L1W
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![BU of 1l1w by Molmil](/molmil-images/mine/1l1w) | NMR structure of a SRP19 binding domain in human SRP RNA | Descriptor: | SRP19 binding domain of SRP RNA | Authors: | Sakamoto, T, Morita, S, Tabata, K, Nakamura, K, Kawai, G. | Deposit date: | 2002-02-20 | Release date: | 2002-05-22 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a SRP19 binding domain in human SRP RNA. J.Biochem.(Tokyo), 132, 2002
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2F87
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![BU of 2f87 by Molmil](/molmil-images/mine/2f87) | Solution structure of a GAAG tetraloop in SRP RNA from Pyrococcus furiosus | Descriptor: | SRP RNA | Authors: | Okada, K, Takahashi, M, Sakamoto, T, Nakamura, K, Kanai, A, Kawai, G | Deposit date: | 2005-12-02 | Release date: | 2006-08-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of a GAAG tetraloop in helix 6 of SRP RNA from Pyrococcus furiosus Nucleosides Nucleotides Nucleic Acids, 25, 2006
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6IUE
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![BU of 6iue by Molmil](/molmil-images/mine/6iue) | DNA helical wire containing Hg(II) | Descriptor: | DNA (5'-D(*TP*TP*TP*GP*C)-3'), MERCURY (II) ION | Authors: | Ono, A, Kanazawa, H, Ito, H, Goto, M, Nakamura, K, Saneyoshi, H, Kondo, J. | Deposit date: | 2018-11-28 | Release date: | 2019-10-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | A Novel DNA Helical Wire Containing HgII-Mediated T:T and T:G Pairs. Angew.Chem.Int.Ed.Engl., 58, 2019
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3AHU
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![BU of 3ahu by Molmil](/molmil-images/mine/3ahu) | Crystal structure of YmaH (Hfq) from Bacillus subtilis in complex with an RNA aptamer. | Descriptor: | 5'-R(*AP*GP*AP*GP*AP*G)-3', Protein hfq | Authors: | Baba, S, Someya, T, Kumasaka, T, Kawai, G, Nakamura, K. | Deposit date: | 2010-04-29 | Release date: | 2011-07-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of YmaH (Hfq) from Bacillus subtilis in complex with an RNA aptamer. To be Published
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3AZV
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![BU of 3azv by Molmil](/molmil-images/mine/3azv) | Crystal structure of the receptor binding domain | Descriptor: | D/C mosaic neurotoxin, SULFATE ION | Authors: | Nuemket, N, Tanaka, Y, Tsukamoto, K, Tsuji, T, Nakamura, K, Kozaki, S, Yao, M, Tanaka, I. | Deposit date: | 2011-06-02 | Release date: | 2011-12-28 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural and mutational analyses of the receptor binding domain of botulinum D/C mosaic neurotoxin: insight into the ganglioside binding mechanism Biochem.Biophys.Res.Commun., 411, 2011
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3AZW
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![BU of 3azw by Molmil](/molmil-images/mine/3azw) | Crystal structure of the receptor binding domain | Descriptor: | D/C mosaic neurotoxin, SULFATE ION | Authors: | Nuemket, N, Tanaka, Y, Tsukamoto, K, Tsuji, T, Nakamura, K, Kozaki, S, Yao, M, Tanaka, I. | Deposit date: | 2011-06-02 | Release date: | 2011-12-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Structural and mutational analyses of the receptor binding domain of botulinum D/C mosaic neurotoxin: insight into the ganglioside binding mechanism Biochem.Biophys.Res.Commun., 411, 2011
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3ALR
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![BU of 3alr by Molmil](/molmil-images/mine/3alr) | Crystal structure of Nanos | Descriptor: | Nanos protein, ZINC ION | Authors: | Hashimoto, H, Hara, K, Hishiki, A, Kawaguchi, S, Shichijo, N, Nakamura, K, Unzai, S, Tamaru, Y, Shimizu, T, Sato, M. | Deposit date: | 2010-08-06 | Release date: | 2011-02-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of zinc-finger domain of Nanos and its functional implications Embo Rep., 11, 2010
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4ZTD
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![BU of 4ztd by Molmil](/molmil-images/mine/4ztd) | Crystal Structure of Human PCNA in complex with a TRAIP peptide | Descriptor: | ALA-GLY-ALA-GLY-ALA, ALA-PHE-GLN-ALA-LYS-LEU-ASP-THR-PHE-LEU-TRP-SER, Proliferating cell nuclear antigen | Authors: | Montoya, G, Mortuza, G.B, Blanco, F.J, Ibanez de Opakua, A. | Deposit date: | 2015-05-14 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J.Cell Biol., 212, 2016
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5UJJ
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![BU of 5ujj by Molmil](/molmil-images/mine/5ujj) | |
5UJI
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2RNT
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![BU of 2rnt by Molmil](/molmil-images/mine/2rnt) | THREE-DIMENSIONAL STRUCTURE OF RIBONUCLEASE T1 COMPLEXED WITH GUANYLYL-2(PRIME),5(PRIME)-GUANOSINE AT 1.8 ANGSTROMS RESOLUTION | Descriptor: | CALCIUM ION, GUANYLYL-2',5'-PHOSPHOGUANOSINE, RIBONUCLEASE T1 | Authors: | Saenger, W, Koepke, J, Maslowska, M, Heinemann, U. | Deposit date: | 1988-07-06 | Release date: | 1989-10-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Three-dimensional structure of ribonuclease T1 complexed with guanylyl-2',5'-guanosine at 1.8 A resolution. J.Mol.Biol., 206, 1989
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3RNT
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![BU of 3rnt by Molmil](/molmil-images/mine/3rnt) | CRYSTAL STRUCTURE OF GUANOSINE-FREE RIBONUCLEASE T1, COMPLEXED WITH VANADATE(V), SUGGESTS CONFORMATIONAL CHANGE UPON SUBSTRATE BINDING | Descriptor: | CALCIUM ION, RIBONUCLEASE T1, VANADATE ION | Authors: | Kostrewa, D, Choe, H.-W, Heinemann, U, Saenger, W. | Deposit date: | 1989-05-31 | Release date: | 1989-10-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of guanosine-free ribonuclease T1, complexed with vanadate (V), suggests conformational change upon substrate binding. Biochemistry, 28, 1989
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1WXZ
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![BU of 1wxz by Molmil](/molmil-images/mine/1wxz) | Crystal structure of adenosine deaminase ligated with a potent inhibitor | Descriptor: | 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | Authors: | Kinoshita, T. | Deposit date: | 2005-02-02 | Release date: | 2005-08-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism J.Med.Chem., 48, 2005
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4F9M
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![BU of 4f9m by Molmil](/molmil-images/mine/4f9m) | Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator | Descriptor: | (9aS)-8-acetyl-N-[(2-ethyl-4-fluoronaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, Peroxisome proliferator-activated receptor gamma, peptide from Nuclear receptor coactivator 1 | Authors: | Matsui, Y, Hanzawa, H. | Deposit date: | 2012-05-19 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators Eur.J.Med.Chem., 54, 2012
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7C3G
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![BU of 7c3g by Molmil](/molmil-images/mine/7c3g) | Crystal structure of human ALK2 kinase domain with R206H mutation in complex with a bicyclic pyrazole inhibitor RK-73134 | Descriptor: | 1,2-ETHANEDIOL, Activin receptor type-1, SULFATE ION, ... | Authors: | Sakai, N, Mishima-Tsumagari, C, Matsumoto, T, Shirouzu, M. | Deposit date: | 2020-05-12 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva. Bioorg.Med.Chem.Lett., 38, 2021
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4L7F
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![BU of 4l7f by Molmil](/molmil-images/mine/4l7f) | Co-crystal Structure of JNK1 and AX13587 | Descriptor: | Mitogen-activated protein kinase 8, N-[1-(4-fluorophenyl)cyclopropyl]-4-[(trans-4-hydroxycyclohexyl)amino]imidazo[1,2-a]quinoxaline-8-carboxamide | Authors: | Walter, R.L, Ranieri, G.M, Riggs, A.M, Weissig, H, Li, B, Shreder, K.R. | Deposit date: | 2013-06-13 | Release date: | 2013-08-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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1V7A
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![BU of 1v7a by Molmil](/molmil-images/mine/1v7a) | Crystal structures of adenosine deaminase complexed with potent inhibitors | Descriptor: | 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE, ZINC ION, adenosine deaminase | Authors: | Kinoshita, T. | Deposit date: | 2003-12-14 | Release date: | 2004-12-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors J.Med.Chem., 47, 2004
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