3VW8

Crystal structure of human c-Met kinase domain with its inhibitor

Summary for 3VW8

Entry DOI	10.2210/pdb3vw8/pdb
Descriptor	Hepatocyte growth factor receptor, N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains	1
Total formula weight	37593.85
Authors	Matsumoto, S.,Miyamoto, N.,Hirayama, T.,Oki, H.,Okada, K.,Tawada, M.,Iwata, H.,Miki, H.,Nakamura, K.,Hori, A.,Imamura, S. (deposition date: 2012-08-08, release date: 2013-08-14, Last modification date: 2022-08-24)
Primary citation	Matsumoto, S.,Miyamoto, N.,Hirayama, T.,Oki, H.,Okada, K.,Tawada, M.,Iwata, H.,Nakamura, K.,Yamasaki, S.,Miki, H.,Hori, A.,Imamura, S. Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors. Bioorg.Med.Chem., 21:7686-7698, 2013 Cited by PubMed: 24216091 DOI: 10.1016/j.bmc.2013.10.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation