3VW8
Crystal structure of human c-Met kinase domain with its inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hepatocyte growth factor receptor | polymer | 328 | 37084.9 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
| 2 | A | N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide | non-polymer | 473.5 | 1 | Chemie (DF6) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A: 1025 - 1352 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| - | Ala 1057 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37084.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 509.0 | |
| All* | Total formula weight | 37593.8 |
