5AX7
| yeast pyruvyltransferase Pvg1p | Descriptor: | Pyruvyl transferase 1, ZINC ION | Authors: | Kanekiyo, M, Yoritsune, K, Yoshinaga, S, Higuchi, Y, Takegawa, K, Kakuta, Y. | Deposit date: | 2015-07-16 | Release date: | 2016-06-08 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | A rationally engineered yeast pyruvyltransferase Pvg1p introduces sialylation-like properties in neo-human-type complex oligosaccharide Sci Rep, 6, 2016
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5TR8
| Crystal structure of vaccine-elicited pan- influenza H1N1 neutralizing murine antibody 441D6. | Descriptor: | 441D6 Fab Heavy chain, 441D6 Fab Light chain, NICKEL (II) ION | Authors: | Joyce, M.G, Kanekiyo, M, Mascola, J.R, Graham, B.S, Kwong, P.D. | Deposit date: | 2016-10-25 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Nat.Immunol., 20, 2019
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8GAT
| Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v), based on consensus cryo-EM map with only Fab 1G01 resolved | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1G01, heavy chain, ... | Authors: | Tsybovsky, Y, Lederhofer, J, Kwong, P.D, Kanekiyo, M. | Deposit date: | 2023-02-23 | Release date: | 2024-02-28 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase. Immunity, 57, 2024
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8GAU
| Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1G01, heavy chain, ... | Authors: | Tsybovsky, Y, Lederhofer, J, Kwong, P.D, Kanekiyo, M. | Deposit date: | 2023-02-23 | Release date: | 2024-02-28 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase. Immunity, 57, 2024
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8GAV
| Structure of human NDS.3 Fab in complex with influenza virus neuraminidase from A/Darwin/09/2021 (H3N2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab NDS.3, heavy chain, ... | Authors: | Tsybovsky, Y, Lederhofer, J, Kwong, P.D, Kanekiyo, M. | Deposit date: | 2023-02-23 | Release date: | 2024-02-28 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase. Immunity, 57, 2024
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7S0J
| Crystal structure of Epstein-Barr virus gH/gL targeting antibody 769B10 | Descriptor: | 769B10 Fab Heavy chain, 769B10 Fab Light chain, GLYCEROL | Authors: | Chen, W.-H, Kanekiyo, M, Cohen, J.I, Joyce, M.G. | Deposit date: | 2021-08-30 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. Immunity, 55, 2022
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7S1B
| Crystal structure of Epstein-Barr virus glycoproteins gH/gL/gp42-peptide in complex with human neutralizing antibodies 769C2 and 770F7 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 769C2 Fab heavy chain, 769C2 Fab light chain, ... | Authors: | Chen, W.-H, Cohen, J.I, Kanekiyo, M, Joyce, M.G. | Deposit date: | 2021-09-02 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. Immunity, 55, 2022
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7S07
| Crystal structure of Epstein-Barr virus glycoprotein gH/gL/gp42-peptide in complex with human neutralizing antibodies 769B10 and 769C2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 769B10 Fab heavy chain, 769B10 Fab light chain, ... | Authors: | Chen, W.-H, Kanekiyo, M, Cohen, J.I, Joyce, M.G. | Deposit date: | 2021-08-30 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. Immunity, 55, 2022
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8SEF
| Crystal structure of Cy137C02, a monoclonal antibody isolated from macaques immunized with an Epstein-Barr virus glycoprotein 350 (gp350) nanoparticle vaccine | Descriptor: | Cy137C02 Fab heavy chain, Cy137C02 Fab light chain, GLYCEROL, ... | Authors: | Joyce, M.G, Jensen, J.L, Chen, W.H, Kanekiyo, M. | Deposit date: | 2023-04-09 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Crystal structure of Cy137C02, a monoclonal antibody isolated from macaques immunized with an Epstein-Barr virus glycoprotein 350 (gp350) nanoparticle vaccine To Be Published
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8SGN
| Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy651H02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Joyce, M.G, Jensen, J.L, Chen, W.H, Kanekiyo, M. | Deposit date: | 2023-04-12 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy651H02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine To Be Published
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8SGG
| Crystal structure of Cy137D09, a monoclonal antibody isolated from macaques immunized with an Epstein-Barr virus glycoprotein 350 (gp350) nanoparticle vaccine | Descriptor: | Cy137D09 Fab heavy chain, Cy137D09 Fab light chain, GLYCEROL | Authors: | Joyce, M.G, Jensen, J.L, Chen, W.H, Kanekiyo, M. | Deposit date: | 2023-04-12 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal structure of Cy137D09, a monoclonal antibody isolated from macaques immunized with an Epstein-Barr virus glycoprotein 350 (gp350) nanoparticle vaccine To Be Published
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8SIC
| Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cy137C02 Fab heavy chain, Cy137C02 Fab light chain, ... | Authors: | Joyce, M.G, Jensen, J.L, Chen, W.H, Kanekiyo, M. | Deposit date: | 2023-04-14 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine To Be Published
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8SM1
| CRYSTAL STRUCTURE OF HUMAN ANTIBODY 769A9 IN COMPLEX WITH EPSTEIN-BARR VIRUS MAJOR GLYCOPROTEIN GP350 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 769A9 Fab heavy chain, 769A9 Fab light chain, ... | Authors: | Chen, W.-H, Bu, W, Cohen, J.I, Kanekiyo, M, Joyce, M.G. | Deposit date: | 2023-04-25 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Structural Basis For Receptor Engagement And Virus Neutralization Through Epstein-Barr Virus Gp350 To Be Published
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8SM0
| Crystal structure of human complement receptor 2 (CD21) in complex with Epstein-Barr virus major glycoprotein gp350 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement receptor type 2, Envelope glycoprotein gp350, ... | Authors: | Chen, W.-H, Bu, W, Cohen, J.I, Kanekiyo, M, Joyce, M.G. | Deposit date: | 2023-04-25 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structural Basis For Receptor Engagement And Virus Neutralization Through Epstein-Barr Virus Gp350 To Be Published
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5X2B
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5FHC
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7SCO
| Structure of H1 influenza hemagglutinin bound to Fab 310-39G10 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 310-39G10 Fab, ... | Authors: | Torrents de la Pena, A, Ward, A.B. | Deposit date: | 2021-09-28 | Release date: | 2022-08-24 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus. Immunity, 55, 2022
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7SCN
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8D21
| Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer | Descriptor: | 1B06 Heavy Chain, 1B06 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2022-05-27 | Release date: | 2023-04-12 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans. Sci Transl Med, 15, 2023
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6XSK
| Cryo-EM Structure of Vaccine-Elicited Rhesus Antibody 789-203-3C12 in Complex with Stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 789-203-3C12 Fab Heavy Chain, ... | Authors: | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | Deposit date: | 2020-07-15 | Release date: | 2021-07-21 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses. Immunity, 55, 2022
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7KNA
| Localized reconstruction of the H1 A/Michigan/45/2015 ectodomain displayed at the surface of I53_dn5 nanoparticle | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin,I53_dn5 | Authors: | Acton, O.J, Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2020-11-04 | Release date: | 2021-03-31 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Quadrivalent influenza nanoparticle vaccines induce broad protection. Nature, 592, 2021
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3E6F
| MHC CLASS I H-2Dd Heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PA9, from the Human immunodeficiency virus (BaL) envelope glycoprotein 120 | Descriptor: | BETA-2 MICROGLOBULIN, Envelope glycoprotein 9-residue peptide, H-2 class I histocompatibility antigen, ... | Authors: | Wang, R, Natarajan, K, Robinson, H, Margulies, D.H. | Deposit date: | 2008-08-15 | Release date: | 2009-08-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity J.Immunol., 183, 2009
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3E6H
| MHC CLASS I H-2Dd heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PI10, from the human immunodeficiency virus (BaL) envelope glycoprotein 120 | Descriptor: | Envelope glycoprotein 10-residue peptide, H-2 class I histocompatibility antigen, D-D alpha chain, ... | Authors: | Wang, R, Natarajan, K, Robinson, H, Margulies, D.H. | Deposit date: | 2008-08-15 | Release date: | 2009-08-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity J.Immunol., 183, 2009
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7KC1
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6C6X
| Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque. | Descriptor: | JC57-14 Heavy chain, JC57-14 Light chain | Authors: | Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D. | Deposit date: | 2018-01-19 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape. J. Virol., 92, 2018
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