5FHC

Crystal Structure of Protective Human Antibodies 100 and 114 in Complex with Ebola Virus Fusion Glycoprotein (GP)

Summary for 5FHC

• Entry DOI: 10.2210/pdb5fhc/pdb
• Related: 5FHA 5FHB
• Descriptor: Envelope glycoprotein, Envelope glycoprotein,Envelope glycoprotein, Antibody 100 Fab heavy chain, ... (6 entities in total)
• Functional Keywords: ig domain, fab, immune system, fusion, ebola virus, glycoprotein, gp, viral protein-immune system complex, viral protein/immune system
• Biological source: Zaire ebolavirus (strain Mayinga-76) (ZEBOV); More
• Cellular location: GP2: Virion membrane ; Single-pass type I membrane protein . GP1: Virion membrane ; Peripheral membrane protein. GP2-delta: Secreted : Q05320 Q05320
• Total number of polymer chains: 6
• Total formula weight: 139919.80

Authors

Gilman, M.S.A.,McLellan, J.S. (deposition date: 2015-12-21, release date: 2016-03-16, Last modification date: 2016-03-30)

• Primary citation: Misasi, J.,Gilman, M.S.,Kanekiyo, M.,Gui, M.,Cagigi, A.,Mulangu, S.,Corti, D.,Ledgerwood, J.E.,Lanzavecchia, A.,Cunningham, J.,Muyembe-Tamfun, J.J.,Baxa, U.,Graham, B.S.,Xiang, Y.,Sullivan, N.J.,McLellan, J.S.; Structural and molecular basis for Ebola virus neutralization by protective human antibodies.; Science, 351:1343-1346, 2016; PubMed: 26917592; DOI: 10.1126/science.aad6117

Experimental method

X-RAY DIFFRACTION (6.704 Å)