8GAT

Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v), based on consensus cryo-EM map with only Fab 1G01 resolved

Summary for 8GAT

• Entry DOI: 10.2210/pdb8gat/pdb
• EMDB information: 29907 29908 29909
• Descriptor: Vasodilator-stimulated phosphoprotein, Neuraminidase chimera, Fab 1G01, heavy chain, Fab 1G01, light chain, ... (4 entities in total)
• Functional Keywords: neuraminidase, antibody, influenza, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 102342.24

Authors

Tsybovsky, Y.,Lederhofer, J.,Kwong, P.D.,Kanekiyo, M. (deposition date: 2023-02-23, release date: 2024-02-28, Last modification date: 2024-04-24)

• Primary citation: Lederhofer, J.,Tsybovsky, Y.,Nguyen, L.,Raab, J.E.,Creanga, A.,Stephens, T.,Gillespie, R.A.,Syeda, H.Z.,Fisher, B.E.,Skertic, M.,Yap, C.,Schaub, A.J.,Rawi, R.,Kwong, P.D.,Graham, B.S.,McDermott, A.B.,Andrews, S.F.,King, N.P.,Kanekiyo, M.; Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.; Immunity, 57:574-586.e7, 2024; PubMed: 38430907; DOI: 10.1016/j.immuni.2024.02.003

Experimental method

ELECTRON MICROSCOPY (3 Å)