7S0J

Crystal structure of Epstein-Barr virus gH/gL targeting antibody 769B10

Summary for 7S0J

Entry DOI	10.2210/pdb7s0j/pdb
Descriptor	769B10 Fab Light chain, 769B10 Fab Heavy chain, GLYCEROL, ... (4 entities in total)
Functional Keywords	antibody, fab, immune system, gh/gl, epstein-barr virus, herpesvirus
Biological source	Homo sapiens More
Total number of polymer chains	2
Total formula weight	48900.45
Authors	Chen, W.-H.,Kanekiyo, M.,Cohen, J.I.,Joyce, M.G. (deposition date: 2021-08-30, release date: 2022-11-09, Last modification date: 2023-10-18)
Primary citation	Chen, W.H.,Kim, J.,Bu, W.,Board, N.L.,Tsybovsky, Y.,Wang, Y.,Hostal, A.,Andrews, S.F.,Gillespie, R.A.,Choe, M.,Stephens, T.,Yang, E.S.,Pegu, A.,Peterson, C.E.,Fisher, B.E.,Mascola, J.R.,Pittaluga, S.,McDermott, A.B.,Kanekiyo, M.,Joyce, M.G.,Cohen, J.I. Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. Immunity, 55:2135-2148.e6, 2022 Cited by PubMed: 36306784 DOI: 10.1016/j.immuni.2022.10.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation