2ELA
 
 | | Crystal Structure of the PTB domain of human APPL1 | | Descriptor: | Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 | | Authors: | Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. | | Deposit date: | 2007-03-27 | | Release date: | 2007-05-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of the BAR-PH and PTB Domains of Human APPL1
Structure, 15, 2007
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2ELB
 | | Crystal Structure of the BAR-PH domain of human APPL1 | | Descriptor: | Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 | | Authors: | Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. | | Deposit date: | 2007-03-27 | | Release date: | 2007-05-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structures of the BAR-PH and PTB Domains of Human APPL1
Structure, 15, 2007
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3T2S
 | | HSP90 N-terminal domain bound to AGS | | Descriptor: | Heat shock protein HSP 90-alpha, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Li, J. | | Deposit date: | 2011-07-23 | | Release date: | 2012-01-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.501 Å) | | Cite: | HSP90 N-terminal domain bound to AGS
To be published
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6JLE
 | | Crystal structure of MORN4/Myo3a complex | | Descriptor: | CITRIC ACID, GLYCEROL, MORN repeat-containing protein 4, ... | | Authors: | Li, J, Liu, H, Raval, M.H, Wan, J, Yengo, C.M, Liu, W, Zhang, M. | | Deposit date: | 2019-03-05 | | Release date: | 2019-07-24 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure of the MORN4/Myo3a Tail Complex Reveals MORN Repeats as Protein Binding Modules.
Structure, 27, 2019
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8W6I
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8W6J
 | | Cryo-EM structure of Escherichia coli Str K12 FtsE(E163Q)X/EnvC complex with ATP in peptidisc | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | | Authors: | Li, J, Xu, X, He, Y, Luo, M. | | Deposit date: | 2023-08-29 | | Release date: | 2023-12-20 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structure of Escherichia coli Str K12 FtsE(E163Q)X/EnvC complex with ATP in peptidisc
To Be Published
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8W1Y
 | | 2.30 angstrom resolution intermediate crystal structure of KatG from Mycobacterium tuberculosis with an MYW-OOH cofactor soaked with peroxide for 1 minute | | Descriptor: | Catalase-peroxidase, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Li, J, Duan, R, Liu, A. | | Deposit date: | 2024-02-19 | | Release date: | 2024-10-23 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Indole N-Linked Hydroperoxyl Adduct of Protein-Derived Cofactor Modulating Catalase-Peroxidase Functions.
Angew.Chem.Int.Ed.Engl., 63, 2024
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8JQ9
 | | Structure of Gabija GajA | | Descriptor: | Endonuclease GajA | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8JQC
 | | Structure of Gabija GajA-GajB 4:1 complex | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8JQB
 | | Structure of Gabija GajA-GajB 4:4 Complex | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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3T1K
 | | HSP90 N-terminal domain bound to ANP | | Descriptor: | Heat shock protein HSP 90-alpha, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Li, J. | | Deposit date: | 2011-07-22 | | Release date: | 2012-01-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | HSP90 N-terminal domain bound to ANP
To be published
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7VFP
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | | Authors: | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | Deposit date: | 2021-09-13 | | Release date: | 2022-11-09 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (4.03 Å) | | Cite: | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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8FLM
 | | Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53 | | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, ... | | Authors: | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | | Deposit date: | 2022-12-21 | | Release date: | 2023-11-01 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Activation of human STING by a molecular glue-like compound.
Nat.Chem.Biol., 20, 2024
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8FLK
 | | Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2 | | Descriptor: | 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, cGAMP | | Authors: | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | | Deposit date: | 2022-12-21 | | Release date: | 2023-11-01 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Activation of human STING by a molecular glue-like compound.
Nat.Chem.Biol., 20, 2024
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5WSU
 | | Crystal structure of Myosin VIIa IQ5-SAH in complex with apo-CaM | | Descriptor: | Calmodulin, Unconventional myosin-VIIa | | Authors: | Li, J, Chen, Y, Deng, Y, Lu, Q, Zhang, M. | | Deposit date: | 2016-12-08 | | Release date: | 2017-06-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension
Structure, 25, 2017
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5X07
 | | Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site | | Descriptor: | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Hepatocyte nuclear factor 3-beta | | Authors: | Li, J, Guo, M, Zhou, Z, Jiang, L, Chen, X, Qu, L, Wu, D, Chen, Z, Chen, L, Chen, Y. | | Deposit date: | 2017-01-20 | | Release date: | 2017-08-16 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.796 Å) | | Cite: | Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site
Biochemistry, 56, 2017
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5WST
 | | Crystal structure of Myo7a SAH | | Descriptor: | Unconventional myosin-VIIa | | Authors: | Li, J, Chen, Y, Deng, Y, Lu, Q, Zhang, M. | | Deposit date: | 2016-12-08 | | Release date: | 2017-06-07 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension
Structure, 25, 2017
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8HHE
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7W1Y
 | | Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (49-MER), ... | | Authors: | Li, J, Dong, J, Dang, S, Zhai, Y. | | Deposit date: | 2021-11-21 | | Release date: | 2023-02-08 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (2.59 Å) | | Cite: | The human pre-replication complex is an open complex.
Cell, 186, 2023
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5WSV
 | | Crystal structure of Myosin VIIa IQ5 in complex with Ca2+-CaM | | Descriptor: | CALCIUM ION, Calmodulin, SULFATE ION, ... | | Authors: | Li, J, Chen, Y, Deng, Y, Lu, Q, Zhang, M. | | Deposit date: | 2016-12-08 | | Release date: | 2017-06-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension
Structure, 25, 2017
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5XBF
 | | Crystal Structure of Myo7b C-terminal MyTH4-FERM in complex with USH1C PDZ3 | | Descriptor: | ACETATE ION, D-MALATE, GLYCEROL, ... | | Authors: | Li, J, He, Y, Weck, W.L, Lu, Q, Tyska, M.J, Zhang, M. | | Deposit date: | 2017-03-17 | | Release date: | 2017-05-17 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7X8U
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4JOD
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8Z69
 | | Crystal Structure of the second bromodomain of human BRD2 BD2 in complex with the inhibitor Y13195 | | Descriptor: | 1,2-ETHANEDIOL, 7-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-5-methyl-2-(2-phenyl-1H-imidazol-5-yl)furo[3,2-c]pyridin-4(5H)-one, BRD2_HUMAN, ... | | Authors: | Li, J, Hu, Q, Xu, H, Zhao, X, Zhang, C, Zhu, R, Wu, X, Zhang, Y, Xu, Y. | | Deposit date: | 2024-04-18 | | Release date: | 2024-12-11 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors.
J.Med.Chem., 67, 2024
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8ZMQ
 | | Crystal Structure of the second bromodomain of human BRD4 BD2 in complex with the inhibitor Y13190 | | Descriptor: | 2-(2-(adamantan-1-yl)-4-ethyl-1H-imidazol-5-yl)-7-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-5-methylfuro[3,2-c]pyridin-4(5H)-one, BRD4_HUMAN, DIMETHYL SULFOXIDE, ... | | Authors: | Li, J, Hu, Q, Xu, H, Zhao, X, Zhang, C, Zhu, R, Wu, X, Zhang, Y, Xu, Y. | | Deposit date: | 2024-05-23 | | Release date: | 2024-12-11 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors.
J.Med.Chem., 67, 2024
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