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2IO5
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BU of 2io5 by Molmil
Crystal structure of the CIA- histone H3-H4 complex
Descriptor: ASF1A protein, Histone H3.1, Histone H4
Authors:Natsume, R, Akai, Y, Horikoshi, M, Senda, T.
Deposit date:2006-10-10
Release date:2007-02-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4.
Nature, 446, 2007
8OU1
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BU of 8ou1 by Molmil
Crystal structure of the SPOC domain of mouse SPOCD1
Descriptor: CITRATE ANION, SPOC domain-containing protein 1
Authors:Heep, M, Cook, A.G, O'Carroll, D.
Deposit date:2023-04-21
Release date:2024-02-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line.
Mol.Cell, 84, 2024
4X5X
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BU of 4x5x by Molmil
HLA-DR1 mutant bN82A with covalently linked CLIP106-120(M107W)
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain
Authors:Guenther, S, Freund, C.
Deposit date:2014-12-06
Release date:2016-03-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.199 Å)
Cite:MHC class II complexes sample intermediate states along the peptide exchange pathway.
Nat Commun, 7, 2016
4X5W
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BU of 4x5w by Molmil
HLA-DR1 with CLIP102-120(M107W)
Descriptor: HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ...
Authors:Guenther, S, Freund, C.
Deposit date:2014-12-06
Release date:2016-03-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:MHC class II complexes sample intermediate states along the peptide exchange pathway.
Nat Commun, 7, 2016
6AAJ
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BU of 6aaj by Molmil
Crystal structure of JAK2 in complex with peficitinib
Descriptor: 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK2
Authors:Amano, Y, Tateishi, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
6AAM
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BU of 6aam by Molmil
Crystal structure of TYK2 in complex with peficitinib
Descriptor: 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Nomura, N, Tomimoto, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
6AAH
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BU of 6aah by Molmil
Crystal structure of JAK1 in complex with peficitinib
Descriptor: 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK1
Authors:Amano, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
6AAK
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BU of 6aak by Molmil
Crystal structure of JAK3 in complex with peficitinib
Descriptor: 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK3
Authors:Amano, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
4YN8
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BU of 4yn8 by Molmil
Crystal Structure of Response Regulator ChrA in Heme-Sensing Two Component System
Descriptor: MAGNESIUM ION, Response regulator ChrA, SULFATE ION
Authors:Doi, A, Nakamura, H, Shiro, Y, Sugimoto, H.
Deposit date:2015-03-09
Release date:2015-08-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the response regulator ChrA in the haem-sensing two-component system of Corynebacterium diphtheriae.
Acta Crystallogr.,Sect.F, 71, 2015
3DOM
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BU of 3dom by Molmil
Crystal Structure of the complex between Tfb5 and the C-terminal domain of Tfb2
Descriptor: RNA polymerase II transcription factor B subunit 2, RNA polymerase II transcription factor B subunit 5
Authors:Kainov, D.E, Cavarelli, J, Egly, J.M, Poterszman, A.
Deposit date:2008-07-04
Release date:2008-08-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for group A trichothiodystrophy
Nat.Struct.Mol.Biol., 15, 2008
3KHW
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BU of 3khw by Molmil
Crystal structure of the large c-terminal domain of polymerase basic protein 2 from influenza virus a/mexico/indre4487/2009(h1n1)
Descriptor: GLYCEROL, Polymerase PB2
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-10-31
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
3L56
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BU of 3l56 by Molmil
Crystal structure of the large c-terminal domain of polymerase basic protein 2 from influenza virus a/viet nam/1203/2004 (h5n1)
Descriptor: Polymerase PB2
Authors:Staker, B.L, Edwards, T, Eric, S, Raymond, A, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-12-21
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
3KC6
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BU of 3kc6 by Molmil
Crystal structure of the large c-terminal domain of polymerase basic protein 2 from influenza virus a/viet nam/1203/2004 (h5n1)
Descriptor: 1,2-ETHANEDIOL, Polymerase PB2
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-10-20
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
5URM
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BU of 5urm by Molmil
Crystal structure of human BRR2 in complex with T-1206548
Descriptor: 3-(5-{[(2R)-5-amino-2-cyclohexyl-7-oxo-2,3-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl]methyl}furan-2-yl)benzoic acid, U5 small nuclear ribonucleoprotein 200 kDa helicase
Authors:Klein, M.G, Tjhen, R, Qin, L.
Deposit date:2017-02-11
Release date:2017-07-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
5URJ
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BU of 5urj by Molmil
Crystal structure of human BRR2 in complex with T-3905516
Descriptor: 6-benzyl-3-[(2R)-2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-1-benzopyran-7-yl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(3H,8H)-dione, GLYCEROL, U5 small nuclear ribonucleoprotein 200 kDa helicase
Authors:Klein, M.G, Tjhen, R, Qin, L.
Deposit date:2017-02-10
Release date:2017-07-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
5URK
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BU of 5urk by Molmil
Crystal structure of human BRR2 in complex with T-3935799
Descriptor: 6-benzyl-3-[3-(benzyloxy)phenyl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione, GLYCEROL, U5 small nuclear ribonucleoprotein 200 kDa helicase
Authors:Qin, L, Tjhen, R, Klein, M.G.
Deposit date:2017-02-10
Release date:2017-07-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
1JDO
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BU of 1jdo by Molmil
SPERM WHALE MYOGLOBIN (FERROUS, NITRIC OXIDE BOUND)
Descriptor: MYOGLOBIN, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Brucker, E.A, Phillips Jr, G.N.
Deposit date:1998-02-10
Release date:1998-05-27
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nitric oxide myoglobin: crystal structure and analysis of ligand geometry.
Proteins, 30, 1998
7X8W
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BU of 7x8w by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab354
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab354 heavy chain, Ab354 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X91
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BU of 7x91 by Molmil
The SARS-CoV-2 receptor binding domain bound with an Fv-clasp form of a human neutralizing antibody Ab496
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, An Fv-clasp version of the Ab496 heavy chain, An Fv-clasp version of the Ab496 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X8Z
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BU of 7x8z by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab188
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ab188 heavy chain, Ab188 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X8Y
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BU of 7x8y by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab159
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ab159 heavy chain, Ab159 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X90
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BU of 7x90 by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab326
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab326 heavy chain, Ab326 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
7X92
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BU of 7x92 by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab445
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab445 heavy chain, Ab445 light chain, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2022-12-07
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Iscience, 25, 2022
1LOP
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BU of 1lop by Molmil
CYCLOPHILIN A COMPLEXED WITH SUCCINYL-ALA-PRO-ALA-P-NITROANILIDE
Descriptor: CYCLOPHILIN A, SUCCINYL-ALA-PRO-ALA-P-NITROANILIDE
Authors:Konno, M.
Deposit date:1996-06-17
Release date:1996-12-23
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomer.
J.Mol.Biol., 256, 1996
1FHG
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BU of 1fhg by Molmil
HIGH RESOLUTION REFINEMENT OF TELOKIN
Descriptor: TELOKIN
Authors:Tomchick, D.R, Minor, W, Kiyatkin, A, Lewinski, K, Somlyo, A.V, Somlyo, A.P.
Deposit date:2000-08-01
Release date:2000-08-23
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.
J.Mol.Biol., 227, 1992

227933

數據於2024-11-27公開中

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