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7PCG
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BU of 7pcg by Molmil
BurG (holo) in complex with cyclopropane-1,1-dicarboxylate (7): Biosynthesis of cyclopropanol rings in bacterial toxins
Descriptor: GLYCEROL, Ketol-acid reductoisomerase, MAGNESIUM ION, ...
Authors:Trottmann, F, Ishida, K, Ishida, M, Kries, H, Groll, M, Hertweck, C.
Deposit date:2021-08-03
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat.Chem., 14, 2022
2DVJ
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BU of 2dvj by Molmil
phosphorylated Crk-II
Descriptor: V-crk sarcoma virus CT10 oncogene homolog, isoform a
Authors:Kobashigawa, Y, Inagaki, F.
Deposit date:2006-07-31
Release date:2007-05-08
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.
Nat.Struct.Mol.Biol., 14, 2007
8IJU
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BU of 8iju by Molmil
ATP-dependent RNA helicase DDX39A (URH49delta41)
Descriptor: 1,2-ETHANEDIOL, ATP-dependent RNA helicase DDX39A, PHOSPHATE ION, ...
Authors:Mikami, B, Fujita, K, Masuda, S, Kojima, M.
Deposit date:2023-02-28
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.
Nat Commun, 15, 2024
6AAJ
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BU of 6aaj by Molmil
Crystal structure of JAK2 in complex with peficitinib
Descriptor: 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK2
Authors:Amano, Y, Tateishi, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2023-03-08
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
6AAM
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BU of 6aam by Molmil
Crystal structure of TYK2 in complex with peficitinib
Descriptor: 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Nomura, N, Tomimoto, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
6AAH
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BU of 6aah by Molmil
Crystal structure of JAK1 in complex with peficitinib
Descriptor: 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK1
Authors:Amano, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
6AAK
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BU of 6aak by Molmil
Crystal structure of JAK3 in complex with peficitinib
Descriptor: 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK3
Authors:Amano, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
2D7H
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BU of 2d7h by Molmil
Crystal structure of the ccc complex of the N-terminal domain of PriA
Descriptor: DNA (5'-D(P*CP*CP*C)-3'), Primosomal protein N'
Authors:Sasaki, K, Ose, T, Maenaka, K, Masai, H, Kohda, D.
Deposit date:2005-11-21
Release date:2006-11-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
2D7E
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BU of 2d7e by Molmil
Crystal structure of N-terminal domain of PriA from E.coli
Descriptor: Primosomal protein N'
Authors:Sasaki, K, Ose, T, Maenaka, K, Masai, H, Kohda, D.
Deposit date:2005-11-18
Release date:2006-11-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
2D7G
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BU of 2d7g by Molmil
Crystal structure of the aa complex of the N-terminal domain of PriA
Descriptor: DNA (5'-D(P*AP*A)-3'), Primosomal protein N'
Authors:Sasaki, K, Ose, T, Maenaka, K, Masai, H, Kohda, D.
Deposit date:2005-11-21
Release date:2006-11-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
2DWN
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BU of 2dwn by Molmil
Crystal structure of the PriA protein complexed with oligonucleotides
Descriptor: DNA (5'-D(*A*G)-3'), Primosomal protein N'
Authors:Sasaki, K, Ose, T, Tanaka, T, Masai, H, Maenaka, K, Kohda, D.
Deposit date:2006-08-15
Release date:2006-11-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
5B4F
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BU of 5b4f by Molmil
Sulfur Transferase TtuA in complex with iron sulfur cluster
Descriptor: IRON/SULFUR CLUSTER, SULFATE ION, Sulfur Transferase TtuA, ...
Authors:Chen, M, Narai, S, Tanaka, Y, Yao, M.
Deposit date:2016-04-03
Release date:2017-05-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3L56
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BU of 3l56 by Molmil
Crystal structure of the large c-terminal domain of polymerase basic protein 2 from influenza virus a/viet nam/1203/2004 (h5n1)
Descriptor: Polymerase PB2
Authors:Staker, B.L, Edwards, T, Eric, S, Raymond, A, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-12-21
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
2DWL
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BU of 2dwl by Molmil
Crystal structure of the PriA protein complexed with oligonucleotides
Descriptor: 5'-D(*AP*(DC))-3', Primosomal protein N
Authors:Sasaki, K, Ose, T, Tanaka, T, Masai, H, Maenaka, K, Kohda, D.
Deposit date:2006-08-15
Release date:2006-11-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
2DWM
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BU of 2dwm by Molmil
Crystal structure of the PriA protein complexed with oligonucleotides
Descriptor: 5'-D(*AP*T)-3', Primosomal protein N
Authors:Sasaki, K, Ose, T, Tanaka, T, Masai, H, Maenaka, K, Kohda, D.
Deposit date:2006-08-15
Release date:2006-11-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
3KC6
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BU of 3kc6 by Molmil
Crystal structure of the large c-terminal domain of polymerase basic protein 2 from influenza virus a/viet nam/1203/2004 (h5n1)
Descriptor: 1,2-ETHANEDIOL, Polymerase PB2
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-10-20
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
3KHW
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BU of 3khw by Molmil
Crystal structure of the large c-terminal domain of polymerase basic protein 2 from influenza virus a/mexico/indre4487/2009(h1n1)
Descriptor: GLYCEROL, Polymerase PB2
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-10-31
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
1LOP
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BU of 1lop by Molmil
CYCLOPHILIN A COMPLEXED WITH SUCCINYL-ALA-PRO-ALA-P-NITROANILIDE
Descriptor: CYCLOPHILIN A, SUCCINYL-ALA-PRO-ALA-P-NITROANILIDE
Authors:Konno, M.
Deposit date:1996-06-17
Release date:1996-12-23
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomer.
J.Mol.Biol., 256, 1996
7E0G
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BU of 7e0g by Molmil
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418, FAD-adduct
Descriptor: GLYCEROL, IMIDAZOLE, Lysine-specific histone demethylase 1A, ...
Authors:Oki, H.
Deposit date:2021-01-28
Release date:2021-03-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.
Sci Adv, 7, 2021
6E3H
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BU of 6e3h by Molmil
Crystal structure of S9-3-37 bound to H5 influenza hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ...
Authors:Wu, N.C, Wilson, I.A.
Deposit date:2018-07-14
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The D3-9 gene segment encodes for recurring and adaptable binding motifs in broadly neutralizing antibodies to influenza virus
Cell Host Microbe, 2018
4YN8
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BU of 4yn8 by Molmil
Crystal Structure of Response Regulator ChrA in Heme-Sensing Two Component System
Descriptor: MAGNESIUM ION, Response regulator ChrA, SULFATE ION
Authors:Doi, A, Nakamura, H, Shiro, Y, Sugimoto, H.
Deposit date:2015-03-09
Release date:2015-08-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the response regulator ChrA in the haem-sensing two-component system of Corynebacterium diphtheriae.
Acta Crystallogr.,Sect.F, 71, 2015
3VPL
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BU of 3vpl by Molmil
Crystal structure of a 2-fluoroxylotriosyl complex of the Vibrio sp. AX-4 Beta-1,3-xylanase
Descriptor: 3,4-dinitrophenol, Beta-1,3-xylanase XYL4, beta-D-xylopyranose-(1-3)-beta-D-xylopyranose-(1-3)-2-deoxy-2-fluoro-beta-D-xylopyranose, ...
Authors:Watanabe, N, Sakaguchi, K.
Deposit date:2012-03-05
Release date:2013-03-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The crystal structure of a 2-fluoroxylotriosyl complex of the Vibrio sp. AX-4 beta-1,3-xylanase at 1.2 A resolution
To be Published
2IBX
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BU of 2ibx by Molmil
Influenza virus (VN1194) H5 HA
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin
Authors:Yamada, S, Russell, R.J, Gamblin, S.J, Skehel, J.J, Kawaoka, Y.
Deposit date:2006-09-12
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.
Nature, 444, 2006
1TLK
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BU of 1tlk by Molmil
X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION
Descriptor: TELOKIN
Authors:Holden, H.M, Rayment, I.
Deposit date:1992-07-20
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.
J.Mol.Biol., 227, 1992
4X5X
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BU of 4x5x by Molmil
HLA-DR1 mutant bN82A with covalently linked CLIP106-120(M107W)
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain
Authors:Guenther, S, Freund, C.
Deposit date:2014-12-06
Release date:2016-03-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.199 Å)
Cite:MHC class II complexes sample intermediate states along the peptide exchange pathway.
Nat Commun, 7, 2016

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數據於2024-11-06公開中

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