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5URJ

Crystal structure of human BRR2 in complex with T-3905516

Summary for 5URJ
Entry DOI10.2210/pdb5urj/pdb
Related5URK 5URM
DescriptorU5 small nuclear ribonucleoprotein 200 kDa helicase, GLYCEROL, 6-benzyl-3-[(2R)-2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-1-benzopyran-7-yl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(3H,8H)-dione, ... (4 entities in total)
Functional Keywordsbrr2 inhibitor, rna helicase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : O75643
Total number of polymer chains1
Total formula weight199171.19
Authors
Klein, M.G.,Tjhen, R.,Qin, L. (deposition date: 2017-02-10, release date: 2017-07-19, Last modification date: 2024-03-06)
Primary citationIwatani-Yoshihara, M.,Ito, M.,Klein, M.G.,Yamamoto, T.,Yonemori, K.,Tanaka, T.,Miwa, M.,Morishita, D.,Endo, S.,Tjhen, R.,Qin, L.,Nakanishi, A.,Maezaki, H.,Kawamoto, T.
Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60:5759-5771, 2017
Cited by
PubMed: 28586220
DOI: 10.1021/acs.jmedchem.7b00461
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.75 Å)
Structure validation

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