5URK
Crystal structure of human BRR2 in complex with T-3935799
Summary for 5URK
| Entry DOI | 10.2210/pdb5urk/pdb |
| Related | 5URJ 5URM |
| Descriptor | U5 small nuclear ribonucleoprotein 200 kDa helicase, GLYCEROL, 6-benzyl-3-[3-(benzyloxy)phenyl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione (3 entities in total) |
| Functional Keywords | brr2 rna helicase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus : O75643 |
| Total number of polymer chains | 1 |
| Total formula weight | 199112.15 |
| Authors | Qin, L.,Tjhen, R.,Klein, M.G. (deposition date: 2017-02-10, release date: 2017-07-19, Last modification date: 2024-03-06) |
| Primary citation | Iwatani-Yoshihara, M.,Ito, M.,Klein, M.G.,Yamamoto, T.,Yonemori, K.,Tanaka, T.,Miwa, M.,Morishita, D.,Endo, S.,Tjhen, R.,Qin, L.,Nakanishi, A.,Maezaki, H.,Kawamoto, T. Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J. Med. Chem., 60:5759-5771, 2017 Cited by PubMed: 28586220DOI: 10.1021/acs.jmedchem.7b00461 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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