5URM
Crystal structure of human BRR2 in complex with T-1206548
Summary for 5URM
Entry DOI | 10.2210/pdb5urm/pdb |
Related | 5URJ 5URK |
Descriptor | U5 small nuclear ribonucleoprotein 200 kDa helicase, 3-(5-{[(2R)-5-amino-2-cyclohexyl-7-oxo-2,3-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl]methyl}furan-2-yl)benzoic acid (3 entities in total) |
Functional Keywords | brr2 inhibitor, rna helicase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : O75643 |
Total number of polymer chains | 2 |
Total formula weight | 398070.18 |
Authors | Klein, M.G.,Tjhen, R.,Qin, L. (deposition date: 2017-02-11, release date: 2017-07-19, Last modification date: 2024-03-06) |
Primary citation | Iwatani-Yoshihara, M.,Ito, M.,Klein, M.G.,Yamamoto, T.,Yonemori, K.,Tanaka, T.,Miwa, M.,Morishita, D.,Endo, S.,Tjhen, R.,Qin, L.,Nakanishi, A.,Maezaki, H.,Kawamoto, T. Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J. Med. Chem., 60:5759-5771, 2017 Cited by PubMed: 28586220DOI: 10.1021/acs.jmedchem.7b00461 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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