6AAK
Crystal structure of JAK3 in complex with peficitinib
Summary for 6AAK
Entry DOI | 10.2210/pdb6aak/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (3 entities in total) |
Functional Keywords | protein kinase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 132739.29 |
Authors | Amano, Y. (deposition date: 2018-07-18, release date: 2018-08-15, Last modification date: 2018-10-24) |
Primary citation | Hamaguchi, H.,Amano, Y.,Moritomo, A.,Shirakami, S.,Nakajima, Y.,Nakai, K.,Nomura, N.,Ito, M.,Higashi, Y.,Inoue, T. Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor Bioorg. Med. Chem., 26:4971-4983, 2018 Cited by PubMed: 30145050DOI: 10.1016/j.bmc.2018.08.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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