6AAK
Crystal structure of JAK3 in complex with peficitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein kinase JAK3 | polymer | 287 | 32858.4 | 4 | UniProt (P52333) Pfam (PF07714) | Homo sapiens | Janus kinase 3,JAK-3 |
| 2 | E, F, G, H (A, B, C, D) | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | non-polymer | 326.4 | 4 | Chemie (9T6) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 814 - 1100 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Ser 1040 | Cys 1040 | engineered mutation |
| Ser 1048 | Cys 1048 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 131433.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1305.6 | |
| All* | Total formula weight | 132739.3 |
