4YN8
Crystal Structure of Response Regulator ChrA in Heme-Sensing Two Component System
Summary for 4YN8
| Entry DOI | 10.2210/pdb4yn8/pdb |
| Descriptor | Response regulator ChrA, SULFATE ION, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | dna-binding, helix-turn-helix, dna binding protein |
| Biological source | Corynebacterium diphtheriae |
| Total number of polymer chains | 1 |
| Total formula weight | 22193.09 |
| Authors | Doi, A.,Nakamura, H.,Shiro, Y.,Sugimoto, H. (deposition date: 2015-03-09, release date: 2015-08-19, Last modification date: 2023-11-08) |
| Primary citation | Doi, A.,Nakamura, H.,Shiro, Y.,Sugimoto, H. Structure of the response regulator ChrA in the haem-sensing two-component system of Corynebacterium diphtheriae. Acta Crystallogr.,Sect.F, 71:966-971, 2015 Cited by PubMed Abstract: ChrA is a response regulator (RR) in the two-component system involved in regulating the degradation and transport of haem (Fe-porphyrin) in the pathogen Corynebacterium diphtheriae. Here, the crystal structure of full-length ChrA is described at a resolution of 1.8 Å. ChrA consists of an N-terminal regulatory domain, a long linker region and a C-terminal DNA-binding domain. A structural comparison of ChrA with other RRs revealed substantial differences in the relative orientation of the two domains and the conformation of the linker region. The structural flexibility of the linker could be an important feature in rearrangement of the domain orientation to create a dimerization interface to bind DNA during haem-sensing signal transduction. PubMed: 26249683DOI: 10.1107/S2053230X15009838 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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