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5ZZ2
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BU of 5zz2 by Molmil
Crystal structure of PDE5 in complex with inhibitor LW1634
Descriptor: 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ...
Authors:Wu, D, Huang, Y.D, Huang, Y.Y, Luo, H.B.
Deposit date:2018-05-29
Release date:2018-09-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
J. Med. Chem., 61, 2018
7XQ2
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BU of 7xq2 by Molmil
Structure of hSLC19A1+2'3'-cGAMP
Descriptor: Reduced folate transporter, cGAMP
Authors:Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P.
Deposit date:2022-05-06
Release date:2022-10-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
7XPZ
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BU of 7xpz by Molmil
Structure of Apo-hSLC19A1
Descriptor: Reduced folate transporter
Authors:Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P.
Deposit date:2022-05-06
Release date:2022-10-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
7XQ0
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BU of 7xq0 by Molmil
Structure of hSLC19A1+3'3'-CDA
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Reduced folate transporter
Authors:Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P.
Deposit date:2022-05-06
Release date:2022-10-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
7XQ1
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BU of 7xq1 by Molmil
Structure of hSLC19A1+2'3'-CDAS
Descriptor: (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol, Reduced folate transporter
Authors:Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P.
Deposit date:2022-05-06
Release date:2022-10-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
6ACB
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BU of 6acb by Molmil
Crystal structure of PDE5 in complex with inhibitor LW1805
Descriptor: 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-6-{[2-(4-methylpiperazin-1-yl)ethyl]amino}-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ...
Authors:Wu, D, Huang, Y.D, Huang, Y.Y, Luo, H.B.
Deposit date:2018-07-26
Release date:2018-09-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
J. Med. Chem., 61, 2018
7XT2
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BU of 7xt2 by Molmil
Crystal structure of TRIM72
Descriptor: Tripartite motif-containing protein 72, ZINC ION
Authors:Zhou, C, Ma, Y.M, Ding, L.
Deposit date:2022-05-15
Release date:2023-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for TRIM72 oligomerization during membrane damage repair.
Nat Commun, 14, 2023
7XP1
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BU of 7xp1 by Molmil
Crystal structure of PmiR from Pseudomonas aeruginosa
Descriptor: ALPHA-METHYLISOCITRIC ACID, GLYCEROL, Probable transcriptional regulator, ...
Authors:Zhang, Y.X, Liang, H.H, Gan, J.H.
Deposit date:2022-05-02
Release date:2023-04-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa.
Sci Adv, 8, 2022
6B77
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BU of 6b77 by Molmil
Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XII, GLYCEROL, ...
Authors:Dementiev, A.A, Silva, A, Yee, C, Flavin, M.T, Partridge, J.R.
Deposit date:2017-10-03
Release date:2018-03-21
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.
Blood Adv, 2, 2018
6BFP
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BU of 6bfp by Molmil
Bovine trypsin bound to potent inhibitor
Descriptor: 3-{2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl}-6-[(cyclopropylmethyl)carbamoyl]pyridine-2-carboxylic acid, CALCIUM ION, Cationic trypsin
Authors:Partridge, J.R, Choy, R.M.
Deposit date:2017-10-26
Release date:2018-10-31
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.292 Å)
Cite:Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition.
J.Struct.Biol., 206, 2019
6B74
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BU of 6b74 by Molmil
Structures of the two-chain human plasma Factor XIIa co-crystallized with potent inhibitors
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, Coagulation factor XII, ...
Authors:Dementiev, A.A, Partridge, J.R.
Deposit date:2017-10-03
Release date:2018-03-21
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.
Blood Adv, 2, 2018
8FWD
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BU of 8fwd by Molmil
Fast and versatile sequence- independent protein docking for nanomaterials design using RPXDock
Descriptor: O43-rpxdoc-EK1_A, O43-rpxdoc-EK1_B
Authors:Skotheim, R, Borst, A.J, Baker, D.
Deposit date:2023-01-20
Release date:2023-05-10
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock.
Plos Comput.Biol., 19, 2023
8GME
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BU of 8gme by Molmil
Crystal structure of the gp32-Dda-dT17 complex
Descriptor: Dda helicase, ZINC ION, dT17, ...
Authors:He, X, Yun, M.K, White, S.W.
Deposit date:2023-03-24
Release date:2023-06-28
Last modified:2025-01-22
Method:X-RAY DIFFRACTION (4.98 Å)
Cite:Structural and functional insights into the interaction between the bacteriophage T4 DNA processing proteins gp32 and Dda.
Nucleic Acids Res., 52, 2024
8GOF
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BU of 8gof by Molmil
Structure of hSLC19A1+PMX
Descriptor: 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Reduced folate transporter
Authors:Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P.
Deposit date:2022-08-24
Release date:2022-10-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
8GOE
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BU of 8goe by Molmil
Structure of hSLC19A1+5-MTHF
Descriptor: N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, Reduced folate transporter
Authors:Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P.
Deposit date:2022-08-24
Release date:2022-10-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
8F2B
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BU of 8f2b by Molmil
Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
Deposit date:2022-11-07
Release date:2023-08-02
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F0K
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BU of 8f0k by Molmil
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L.
Deposit date:2022-11-03
Release date:2023-08-02
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8G9J
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BU of 8g9j by Molmil
Geometrically programmable nanomaterial construction using regularized protein building blocks
Descriptor: THR1
Authors:Huddy, T, Bera, A.K, Baker, D.
Deposit date:2023-02-21
Release date:2024-03-13
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Blueprinting extendable nanomaterials with standardized protein blocks.
Nature, 627, 2024
8G9K
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BU of 8g9k by Molmil
Geometrically programmable nanomaterial construction using regularized protein building blocks
Descriptor: THR2
Authors:Bera, A.K, Huddy, T, Baker, D, Kang, A.
Deposit date:2023-02-21
Release date:2024-03-13
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Blueprinting extendable nanomaterials with standardized protein blocks.
Nature, 627, 2024
8GA6
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BU of 8ga6 by Molmil
Geometrically programmable nanomaterial construction using regularized protein building blocks
Descriptor: THR6
Authors:Huddy, T, Bera, A.K, Baker, D, Kang, A.
Deposit date:2023-02-22
Release date:2024-03-13
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Blueprinting extendable nanomaterials with standardized protein blocks.
Nature, 627, 2024
8GA7
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BU of 8ga7 by Molmil
Geometrically programmable nanomaterial construction using regularized protein building blocks
Descriptor: THR5
Authors:Huddy, T, Bera, A.K, Baker, D, Kang, A.
Deposit date:2023-02-22
Release date:2024-03-13
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Blueprinting extendable nanomaterials with standardized protein blocks.
Nature, 627, 2024
8F0J
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BU of 8f0j by Molmil
Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
Deposit date:2022-11-03
Release date:2023-08-02
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F2A
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BU of 8f2a by Molmil
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L, Radostin, D.
Deposit date:2022-11-07
Release date:2023-08-02
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8G4K
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BU of 8g4k by Molmil
Complex of TbRII mini protein binder bound to the TbRII ECD
Descriptor: 5HCS_TGFBR2_1, SULFATE ION, TGF-beta receptor type-2
Authors:Schwartze, T.S, Hinck, A.P.
Deposit date:2023-02-09
Release date:2024-08-14
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Computational Design of High Affinity Binders to Convex Protein Target Sites
To be Published
8GAC
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BU of 8gac by Molmil
Crystal structure of a high affinity CTLA-4 binder
Descriptor: 1,2-ETHANEDIOL, CTLA-4 binder
Authors:Yang, W, Almo, S.C, Baker, D, Ghosh, A.
Deposit date:2023-02-22
Release date:2024-08-21
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Design of High Affinity Binders to Convex Protein Target Sites.
Biorxiv, 2024

238582

數據於2025-07-09公開中

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