6B74

Structures of the two-chain human plasma Factor XIIa co-crystallized with potent inhibitors

Summary for 6B74

• Entry DOI: 10.2210/pdb6b74/pdb
• Related: 6B77
• Descriptor: Coagulation factor XII, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ... (8 entities in total)
• Functional Keywords: coagulation factor, two-chain factor xiia, benzamidine inhibitor, covalent synthetic inhibitor, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28334.14

Authors

Dementiev, A.A.,Partridge, J.R. (deposition date: 2017-10-03, release date: 2018-03-21, Last modification date: 2023-10-04)

• Primary citation: Dementiev, A.,Silva, A.,Yee, C.,Li, Z.,Flavin, M.T.,Sham, H.,Partridge, J.R.; Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.; Blood Adv, 2:549-558, 2018; PubMed: 29519898; DOI: 10.1182/bloodadvances.2018016337

Experimental method

X-RAY DIFFRACTION (2.323 Å)