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6ACB

Crystal structure of PDE5 in complex with inhibitor LW1805

Summary for 6ACB
Entry DOI10.2210/pdb6acb/pdb
DescriptorcGMP-specific 3',5'-cyclic phosphodiesterase, SULFATE ION, ZINC ION, ... (6 entities in total)
Functional Keywordspde5 in complex with inhibitor lw1805, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight38535.94
Authors
Wu, D.,Huang, Y.D.,Huang, Y.Y.,Luo, H.B. (deposition date: 2018-07-26, release date: 2018-09-19, Last modification date: 2023-11-22)
Primary citationWu, D.,Huang, Y.,Chen, Y.,Huang, Y.Y.,Geng, H.,Zhang, T.,Zhang, C.,Li, Z.,Guo, L.,Chen, J.,Luo, H.B.
Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
J. Med. Chem., 61:8468-8473, 2018
Cited by
PubMed: 30148362
DOI: 10.1021/acs.jmedchem.8b01209
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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