6ACB
Crystal structure of PDE5 in complex with inhibitor LW1805
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 901 |
| Chain | Residue |
| A | HIS613 |
| A | HIS617 |
| A | ASP654 |
| A | ASP764 |
| A | ZN902 |
| A | 9T9904 |
| A | HOH1002 |
| A | HOH1011 |
| A | HOH1023 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 902 |
| Chain | Residue |
| A | HIS617 |
| A | HIS653 |
| A | ASP654 |
| A | ASP764 |
| A | SO4901 |
| A | MG903 |
| A | HOH1002 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue MG A 903 |
| Chain | Residue |
| A | HIS653 |
| A | ASP654 |
| A | THR723 |
| A | ZN902 |
| A | HOH1001 |
| A | HOH1002 |
| A | HOH1006 |
| A | HOH1007 |
| A | HOH1011 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue 9T9 A 904 |
| Chain | Residue |
| A | VAL660 |
| A | PRO671 |
| A | GLN674 |
| A | ILE768 |
| A | ALA783 |
| A | PHE786 |
| A | PHE787 |
| A | ILE813 |
| A | MET816 |
| A | GLN817 |
| A | PHE820 |
| A | SO4901 |
| A | HOH1023 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY |
| Chain | Residue | Details |
| A | HIS653-TYR664 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
