6ACB
Crystal structure of PDE5 in complex with inhibitor LW1805
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 326 | 37788.5 | 1 | UniProt (O76074) Pfam (PF00233) | Homo sapiens (Human) | cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-6-{[2-(4-methylpiperazin-1-yl)ethyl]amino}-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one | non-polymer | 561.6 | 1 | Chemie (9T9) | |||
| 6 | F (A) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37788.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 747.4 | |
| All* | Total formula weight | 38535.9 |
