5ZZ2

Crystal structure of PDE5 in complex with inhibitor LW1634

Summary for 5ZZ2

Entry DOI	10.2210/pdb5zz2/pdb
Descriptor	cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	pde5 inhibitor lw1634, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	38394.72
Authors	Wu, D.,Huang, Y.D.,Huang, Y.Y.,Luo, H.B. (deposition date: 2018-05-29, release date: 2018-09-19, Last modification date: 2023-11-22)
Primary citation	Wu, D.,Huang, Y.,Chen, Y.,Huang, Y.Y.,Geng, H.,Zhang, T.,Zhang, C.,Li, Z.,Guo, L.,Chen, J.,Luo, H.B. Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. J. Med. Chem., 61:8468-8473, 2018 Cited by PubMed: 30148362 DOI: 10.1021/acs.jmedchem.8b01209 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation