9NZH
 
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9L04
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7OZV
 | | SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with G | | Descriptor: | Non-structural protein 7, Non-structural protein 8, Product RNA, ... | | Authors: | Kabinger, F, Stiller, C, Schmitzova, J, Dienemann, C, Kokic, G, Hillen, H.S, Hoebartner, C, Cramer, P. | | Deposit date: | 2021-06-28 | | Release date: | 2021-08-18 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis.
Nat.Struct.Mol.Biol., 28, 2021
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7OZU
 | | SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with A | | Descriptor: | Non-structural protein 7, Non-structural protein 8, Product RNA, ... | | Authors: | Kabinger, F, Stiller, C, Schmitzova, J, Dienemann, C, Kokic, G, Hillen, H.S, Hoebartner, C, Cramer, P. | | Deposit date: | 2021-06-28 | | Release date: | 2021-08-18 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis.
Nat.Struct.Mol.Biol., 28, 2021
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9I69
 | | Crystal structure of human Cdc20 bound to synthetic D-box peptide D20 | | Descriptor: | ARG-ALA-PRO-0JY-SER-ASP, Cell division cycle protein 20 homolog | | Authors: | Eapen, R, Okoye, C, Stubbs, C, Schimpl, M, Tischer, T, Fisher, E.J, Zacharopoulou, M, Ferrer, F, Barford, D, Spring, D, Lindon, C, Phillips, C, Itzhaki, L.S. | | Deposit date: | 2025-01-29 | | Release date: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (1.463 Å) | | Cite: | Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
To be published
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9I6A
 | | Crystal structure of human Cdc20 bound to synthetic D-box peptide D7 | | Descriptor: | ALA-PRO-0JY-GLY, Cell division cycle protein 20 homolog | | Authors: | Eapen, R, Okoye, C, Stubbs, C, Schimpl, M, Tischer, T, Fisher, E.J, Zacharopoulou, M, Ferrer, F, Barford, D, Spring, D, Lindon, C, Phillips, C, Itzhaki, L.S. | | Deposit date: | 2025-01-29 | | Release date: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (1.915 Å) | | Cite: | Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
To be published
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9I68
 | | Crystal structure of human Cdc20 bound to synthetic D-box peptide D21 | | Descriptor: | ARG-ALA-PRO-3EG-SER-ASP, Cell division cycle protein 20 homolog | | Authors: | Eapen, R, Okoye, C, Stubbs, C, Schimpl, M, Tischer, T, Fisher, E.J, Zacharopoulou, M, Ferrer, F, Barford, D, Spring, D, Lindon, C, Phillips, C, Itzhaki, L.S. | | Deposit date: | 2025-01-29 | | Release date: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (1.505 Å) | | Cite: | Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
To be published
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9EOG
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9EOH
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9EO9
 | | SF type tau filament from V337M mutant | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Qi, C, Scheres, S.H.W, Michel, G. | | Deposit date: | 2024-03-14 | | Release date: | 2024-07-10 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.
Nat.Struct.Mol.Biol., 32, 2025
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9EO7
 | | PHF type tau filament from V337M mutant | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Qi, C, Scheres, S.H.W, Michel, G. | | Deposit date: | 2024-03-14 | | Release date: | 2024-07-10 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.
Nat.Struct.Mol.Biol., 32, 2025
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9EOE
 | | TF type tau filament from V337M mutant | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Qi, C, Scheres, S.H.W, Michel, G. | | Deposit date: | 2024-03-14 | | Release date: | 2024-07-10 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.
Nat.Struct.Mol.Biol., 32, 2025
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5J7A
 | | Bacteriorhodopsin ground state structure obtained with Serial Femtosecond Crystallography | | Descriptor: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, RETINAL | | Authors: | Nogly, P, Panneels, V, Nelson, G, Gati, C, Kimura, T, Milne, C, Milathianaki, D, Kubo, M, Wu, W, Conrad, C, Coe, J, Bean, R, Zhao, Y, Bath, P, Dods, R, Harimoorthy, R, Beyerlein, K.R, Rheinberger, J, James, D, DePonte, D, Li, C, Sala, L, Williams, G, Hunter, M, Koglin, J.E, Berntsen, P, Nango, E, Iwata, S, Chapman, H.N, Fromme, P, Frank, M, Abela, R, Boutet, S, Barty, A, White, T.A, Weierstall, U, Spence, J, Neutze, R, Schertler, G, Standfuss, J. | | Deposit date: | 2016-04-06 | | Release date: | 2016-08-31 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography.
Nat Commun, 7, 2016
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5XXH
 | | Crystal Structure Analysis of the CBP | | Descriptor: | (3S)-1-[2-(3-ethanoylindol-1-yl)ethanoyl]piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, CREB-binding protein, ... | | Authors: | Xiang, Q, Zhang, Y, Wang, C, Song, M. | | Deposit date: | 2017-07-04 | | Release date: | 2018-06-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.
Eur J Med Chem, 147, 2018
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5Y93
 | | Crystal Structure Analysis of the BRD4 | | Descriptor: | 1,2-ETHANEDIOL, 2-[[5-[(5-bromanyl-2-methoxy-phenyl)sulfonylamino]-3-methyl-1,2-benzoxazol-6-yl]oxy]-N-(2-morpholin-4-ylethyl)ethanamide, Bromodomain-containing protein 4, ... | | Authors: | Xu, Y, Zhang, Y, Song, M, Wang, C. | | Deposit date: | 2017-08-22 | | Release date: | 2018-06-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61, 2018
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7Y67
 | | Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein | | Descriptor: | C089 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | Deposit date: | 2022-06-18 | | Release date: | 2023-03-01 | | Last modified: | 2023-04-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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7XHP
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7Y65
 | | Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein | | Descriptor: | C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | Deposit date: | 2022-06-18 | | Release date: | 2023-03-01 | | Last modified: | 2023-04-19 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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7Y66
 | | Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein | | Descriptor: | BM213 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | Deposit date: | 2022-06-18 | | Release date: | 2023-03-01 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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7XN1
 | | Crystal structure of human acetylcholinesterase in complex with tacrine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Acetylcholinesterase, ... | | Authors: | Dileep, K.V, Ihara, K, Mishima-Tsumagari, C, Kukimoto-Niino, M, Yonemochi, M, Hanada, K, Shirouzu, M, Zhang, K.Y.J. | | Deposit date: | 2022-04-27 | | Release date: | 2023-03-01 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery
Int.J.Biol.Macromol., 210, 2022
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7Y64
 | | Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | | Descriptor: | C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | Deposit date: | 2022-06-18 | | Release date: | 2023-03-01 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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5Z9R
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7XPT
 | | Crystal structrue of MtdL:GDP:Mn soaked with GDP-Glc | | Descriptor: | GDP-ALPHA-D-GLUCOSE, MANGANESE (II) ION, Transglycosylse | | Authors: | Li, F.D, He, C. | | Deposit date: | 2022-05-05 | | Release date: | 2023-03-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.
J.Biol.Chem., 299, 2023
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7XT2
 | | Crystal structure of TRIM72 | | Descriptor: | Tripartite motif-containing protein 72, ZINC ION | | Authors: | Zhou, C, Ma, Y.M, Ding, L. | | Deposit date: | 2022-05-15 | | Release date: | 2023-03-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for TRIM72 oligomerization during membrane damage repair.
Nat Commun, 14, 2023
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7XPR
 | | Crystal structrue of SeMet-MtdL:GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Transglycosylse | | Authors: | Li, F.D, He, C. | | Deposit date: | 2022-05-05 | | Release date: | 2023-03-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.
J.Biol.Chem., 299, 2023
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