9I6A

Crystal structure of human Cdc20 bound to synthetic D-box peptide D7

Summary for 9I6A

• Entry DOI: 10.2210/pdb9i6a/pdb
• Descriptor: Cell division cycle protein 20 homolog, ALA-PRO-0JY-GLY (3 entities in total)
• Functional Keywords: apc/c, degron, d-box, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 55753.57

Authors

Eapen, R.,Okoye, C.,Stubbs, C.,Schimpl, M.,Tischer, T.,Fisher, E.J.,Zacharopoulou, M.,Ferrer, F.,Barford, D.,Spring, D.,Lindon, C.,Phillips, C.,Itzhaki, L.S. (deposition date: 2025-01-29, release date: 2025-02-12)

• Primary citation: Eapen, R.,Okoye, C.,Stubbs, C.,Schimpl, M.,Tischer, T.,Fisher, E.J.,Zacharopoulou, M.,Ferrer, F.,Barford, D.,Spring, D.,Lindon, C.,Phillips, C.,Itzhaki, L.S.; Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome; To be published,

Experimental method

X-RAY DIFFRACTION (1.915 Å)